DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Seonghui | ko |
dc.contributor.author | Shin, Heegwon | ko |
dc.contributor.author | Lee, Jungmin | ko |
dc.contributor.author | Kim, Youngmi | ko |
dc.contributor.author | Bak, Geunu | ko |
dc.contributor.author | Lee, Younghoon | ko |
dc.date.accessioned | 2017-03-30T09:21:30Z | - |
dc.date.available | 2017-03-30T09:21:30Z | - |
dc.date.created | 2017-03-29 | - |
dc.date.created | 2017-03-29 | - |
dc.date.created | 2017-03-29 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | FEBS LETTERS, v.591, no.2, pp.393 - 405 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/10203/222768 | - |
dc.description.abstract | The long noncoding RNA BC200 ( brain cytoplasmic RNA, 200 nucleotides) acts as a translational modulator of local protein synthesis at dendrites. BC200 RNA has been shown to inhibit translation in vitro, but it remains unknown how this translation inhibition might be controlled in a cell. Here, we performed yeast three-hybrid screening and identified hnRNP E1 and hnRNP E2 as BC200 RNA-interacting proteins. We found that: these hnRNA proteins could restore BC200 RNA-inhibited translation; BC200 RNA interacts with hnRNP E1 and E2 mainly through its unique 30 C-rich domain; and the RNA binding specificities and modes of the two proteins differed somewhat. Our results offer new insights into the regulation of BC200 RNA-mediated translation inhibition. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | LONG NONCODING RNA | - |
dc.subject | DENDRITIC BC1 RNA | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | BINDING-PROTEINS | - |
dc.subject | ERYTHROID-DIFFERENTIATION | - |
dc.subject | POLY(C)-BINDING PROTEINS | - |
dc.subject | POLY(A)-BINDING PROTEIN | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | POLIOVIRUS RNA | - |
dc.subject | BREAST-CANCER | - |
dc.title | Regulation of BC200 RNA-mediated translation inhibition by hnRNP E1 and E2 | - |
dc.type | Article | - |
dc.identifier.wosid | 000393962400016 | - |
dc.identifier.scopusid | 2-s2.0-85010521596 | - |
dc.type.rims | ART | - |
dc.citation.volume | 591 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 393 | - |
dc.citation.endingpage | 405 | - |
dc.citation.publicationname | FEBS LETTERS | - |
dc.identifier.doi | 10.1002/1873-3468.12544 | - |
dc.contributor.localauthor | Lee, Younghoon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | BC200 RNA | - |
dc.subject.keywordAuthor | hnRNP E1 | - |
dc.subject.keywordAuthor | hnRNP E2 | - |
dc.subject.keywordAuthor | regulation of translation | - |
dc.subject.keywordAuthor | RNA-protein interaction | - |
dc.subject.keywordPlus | LONG NONCODING RNA | - |
dc.subject.keywordPlus | DENDRITIC BC1 RNA | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | BINDING-PROTEINS | - |
dc.subject.keywordPlus | ERYTHROID-DIFFERENTIATION | - |
dc.subject.keywordPlus | POLY(C)-BINDING PROTEINS | - |
dc.subject.keywordPlus | POLY(A)-BINDING PROTEIN | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | POLIOVIRUS RNA | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
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