A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract

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dc.contributor.authorOh, Ji Eunko
dc.contributor.authorOh, Dongsunko
dc.contributor.authorJung, Hi Eunko
dc.contributor.authorLee, Heung Kyuko
dc.date.accessioned2017-03-30T09:19:23Z-
dc.date.available2017-03-30T09:19:23Z-
dc.date.created2017-03-20-
dc.date.created2017-03-20-
dc.date.created2017-03-20-
dc.date.issued2017-02-
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.114, no.7, pp.E1188 - E1195-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10203/222734-
dc.description.abstractThe genital mucosa is a barrier that is constantly exposed to a variety of pathogens, allergens, and external stimuli. Although both allergen exposure and parasite infections frequently occur in the genital area, the mechanism by which immune responses-particularly type 2 immunity-are induced has rarely been studied in the genital mucosa. Here, we demonstrate the induction of T helper type 2 (Th2) immunity in the genital mucosa in response to a model allergen, the protease papain. Intravaginal papain immunization induced type 2 immunity in a manner that was dependent on protease activity and the estrous phase of the mice. In addition, IL-33 was released from the vaginal epithelia after intravaginal papain immunization, leading to the activation of type 2 innate lymphoid cells (ILC2s). Moreover, the IL-33-MyD88 (myeloid differentiation primary response gene 88) signaling pathway was critical for the induction of type 2 immunity. We also found that Th2 differentiation in response to intravaginal papain treatment requires a specific dendritic cell (DC) subset that is controlled by interferon regulatory factor 4 (IRF4). These findings suggest that type 2 immunity is induced by a unique mechanism in the genital tract, which is an important, but often overlooked, barrier surface.-
dc.languageEnglish-
dc.publisherNATL ACAD SCIENCES-
dc.titleA mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract-
dc.typeArticle-
dc.identifier.wosid000393989300019-
dc.identifier.scopusid2-s2.0-85012966901-
dc.type.rimsART-
dc.citation.volume114-
dc.citation.issue7-
dc.citation.beginningpageE1188-
dc.citation.endingpageE1195-
dc.citation.publicationnamePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.identifier.doi10.1073/pnas.1612997114-
dc.contributor.localauthorLee, Heung Kyu-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorprotease allergen-
dc.subject.keywordAuthorpapain-
dc.subject.keywordAuthortype 2 immunity-
dc.subject.keywordAuthorgenital tract-
dc.subject.keywordAuthorIL-33-
dc.subject.keywordPlusSIMPLEX-VIRUS TYPE-2-
dc.subject.keywordPlusINNATE LYMPHOID-CELLS-
dc.subject.keywordPlusT-CELLS-
dc.subject.keywordPlusDENDRITIC CELLS-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusRECURRENT VAGINITIS-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusIL-33-
dc.subject.keywordPlusEOSINOPHILS-
dc.subject.keywordPlusINFECTION-
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