DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Ji Eun | ko |
dc.contributor.author | Oh, Dongsun | ko |
dc.contributor.author | Jung, Hi Eun | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.date.accessioned | 2017-03-30T09:19:23Z | - |
dc.date.available | 2017-03-30T09:19:23Z | - |
dc.date.created | 2017-03-20 | - |
dc.date.created | 2017-03-20 | - |
dc.date.created | 2017-03-20 | - |
dc.date.created | 2017-03-20 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.114, no.7, pp.E1188 - E1195 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/222734 | - |
dc.description.abstract | The genital mucosa is a barrier that is constantly exposed to a variety of pathogens, allergens, and external stimuli. Although both allergen exposure and parasite infections frequently occur in the genital area, the mechanism by which immune responses-particularly type 2 immunity-are induced has rarely been studied in the genital mucosa. Here, we demonstrate the induction of T helper type 2 (Th2) immunity in the genital mucosa in response to a model allergen, the protease papain. Intravaginal papain immunization induced type 2 immunity in a manner that was dependent on protease activity and the estrous phase of the mice. In addition, IL-33 was released from the vaginal epithelia after intravaginal papain immunization, leading to the activation of type 2 innate lymphoid cells (ILC2s). Moreover, the IL-33-MyD88 (myeloid differentiation primary response gene 88) signaling pathway was critical for the induction of type 2 immunity. We also found that Th2 differentiation in response to intravaginal papain treatment requires a specific dendritic cell (DC) subset that is controlled by interferon regulatory factor 4 (IRF4). These findings suggest that type 2 immunity is induced by a unique mechanism in the genital tract, which is an important, but often overlooked, barrier surface. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract | - |
dc.type | Article | - |
dc.identifier.wosid | 000393989300019 | - |
dc.identifier.scopusid | 2-s2.0-85012966901 | - |
dc.type.rims | ART | - |
dc.citation.volume | 114 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | E1188 | - |
dc.citation.endingpage | E1195 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1612997114 | - |
dc.contributor.localauthor | Oh, Ji Eun | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | protease allergen | - |
dc.subject.keywordAuthor | papain | - |
dc.subject.keywordAuthor | type 2 immunity | - |
dc.subject.keywordAuthor | genital tract | - |
dc.subject.keywordAuthor | IL-33 | - |
dc.subject.keywordPlus | SIMPLEX-VIRUS TYPE-2 | - |
dc.subject.keywordPlus | INNATE LYMPHOID-CELLS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RECURRENT VAGINITIS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | IL-33 | - |
dc.subject.keywordPlus | EOSINOPHILS | - |
dc.subject.keywordPlus | INFECTION | - |
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