DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, SI | ko |
dc.contributor.author | Jeong, Jaeseung | ko |
dc.contributor.author | Kwak, Y | ko |
dc.contributor.author | Kim, YI | ko |
dc.contributor.author | Jung, SH | ko |
dc.contributor.author | Lee, KJ | ko |
dc.date.accessioned | 2011-02-07T05:53:14Z | - |
dc.date.available | 2011-02-07T05:53:14Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-08 | - |
dc.identifier.citation | JOURNAL OF COMPUTATIONAL NEUROSCIENCE, v.19, pp.39 - 51 | - |
dc.identifier.issn | 0929-5313 | - |
dc.identifier.uri | http://hdl.handle.net/10203/21965 | - |
dc.description.abstract | Individual neurons in the suprachiasmatic nucleus (SCN), the master biological clock in mammals, autonomously produce highly complex patterns of spikes. We have shown that most (similar to 90%) SCN neurons exhibit truly stochastic interspike interval (ISI) patterns. The aim of this study was to understand the stochastic nature of the firing patterns in SCN neurons by analyzing the ISI sequences of 150 SCN neurons in hypothalamic slices. Fractal analysis, using the periodogram, Fano factor, and Allan factor, revealed the presence of a 1/f-type power-law (fractal) behavior in the ISI sequences. This fractal nature was persistent after the application of the GABA(A) receptor antagonist bicuculline, suggesting that the fractal stochastic activity is an intrinsic property of individual SCN neurons. Based on these physiological findings, we developed a computational model for the stochastic SCN neurons to find that their stochastic spiking activity was best described by a gamma point process whose mean firing rate was modulated by a fractal binomial noise. Taken together, we suggest that SCN neurons generate temporal spiking patterns using the fractal stochastic point process. | - |
dc.description.sponsorship | This study was supported by Creative Research Initiatives of the Korean Ministry of Science and Technology. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | SPRINGER | - |
dc.subject | RANGE TEMPORAL CORRELATIONS | - |
dc.subject | ION CHANNEL KINETICS | - |
dc.subject | CIRCADIAN PACEMAKER | - |
dc.subject | VISUAL-SYSTEM | - |
dc.subject | SCALING BEHAVIOR | - |
dc.subject | SPINAL-CORD | - |
dc.subject | IN-VITRO | - |
dc.subject | OSCILLATIONS | - |
dc.subject | CLOCK | - |
dc.subject | CAT | - |
dc.title | Fractal stochastic modeling of spiking activity in suprachiasmatic nucleus neurons | - |
dc.type | Article | - |
dc.identifier.wosid | 000231222700003 | - |
dc.identifier.scopusid | 2-s2.0-24144502941 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.beginningpage | 39 | - |
dc.citation.endingpage | 51 | - |
dc.citation.publicationname | JOURNAL OF COMPUTATIONAL NEUROSCIENCE | - |
dc.identifier.doi | 10.1007/s10827-005-0149-x | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Jeong, Jaeseung | - |
dc.contributor.nonIdAuthor | Kim, SI | - |
dc.contributor.nonIdAuthor | Kwak, Y | - |
dc.contributor.nonIdAuthor | Kim, YI | - |
dc.contributor.nonIdAuthor | Jung, SH | - |
dc.contributor.nonIdAuthor | Lee, KJ | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | suprachiasmatic nucleus | - |
dc.subject.keywordAuthor | interspike intervals | - |
dc.subject.keywordAuthor | fractal | - |
dc.subject.keywordAuthor | stochastic | - |
dc.subject.keywordAuthor | gamma point processes | - |
dc.subject.keywordAuthor | long-term correlations | - |
dc.subject.keywordPlus | RANGE TEMPORAL CORRELATIONS | - |
dc.subject.keywordPlus | ION CHANNEL KINETICS | - |
dc.subject.keywordPlus | CIRCADIAN PACEMAKER | - |
dc.subject.keywordPlus | VISUAL-SYSTEM | - |
dc.subject.keywordPlus | SCALING BEHAVIOR | - |
dc.subject.keywordPlus | SPINAL-CORD | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | OSCILLATIONS | - |
dc.subject.keywordPlus | CLOCK | - |
dc.subject.keywordPlus | CAT | - |
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