A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome

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The three-dimensional configuration of DNA is integral to all nuclear processes in eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide chromosome conformation capture studies have uncovered features of chromatin organization in cultured cells, but genome architecture in human tissues has yet to be explored. Here, we report the most comprehensive survey to date of chromatin organization in human tissues. Through integrative analysis of chromatin contact maps in 21 primary human tissues and cell types, we find topologically associating domains highly conserved in different tissues. We also discover genomic regions that exhibit unusually high levels of local chromatin interactions. These frequently interacting regions (FIREs) are enriched for super-enhancers and are near tissuespecifically expressed genes. They display strong tissue-specificity in local chromatin interactions. Additionally, FIRE formation is partially dependent on CTCF and the Cohesin complex. We further show that FIREs can help annotate the function of non-coding sequence variants.
Publisher
CELL PRESS
Issue Date
2016-11
Language
English
Article Type
Article
Keywords

HI-C DATA; CHROMOSOMAL DOMAIN ARCHITECTURE; ACUTE LYMPHOBLASTIC-LEUKEMIA; GENE-EXPRESSION; REGULATORY LANDSCAPE; INTEGRATIVE ANALYSIS; CELL IDENTITY; ORGANIZATION; COHESIN; CONFORMATION

Citation

CELL REPORTS, v.17, no.8, pp.2042 - 2059

ISSN
2211-1247
DOI
10.1016/j.celrep.2016.10.061
URI
http://hdl.handle.net/10203/219644
Appears in Collection
BS-Journal Papers(저널논문)
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