DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Yong An | ko |
dc.contributor.author | Jeong, Jaeseung | ko |
dc.contributor.author | Yang, Dong Won | ko |
dc.contributor.author | Kang, Bong-Joo | ko |
dc.contributor.author | Kim, Sung Hoon | ko |
dc.contributor.author | Chung, Soo Kyo | ko |
dc.contributor.author | Sohn, Hyung Sun | ko |
dc.contributor.author | Peterson, Bradley S. | ko |
dc.date.accessioned | 2011-02-07T05:42:46Z | - |
dc.date.available | 2011-02-07T05:42:46Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | NEUROIMAGE, v.47, no.1, pp.50 - 55 | - |
dc.identifier.issn | 1053-8119 | - |
dc.identifier.uri | http://hdl.handle.net/10203/21962 | - |
dc.description.abstract | Objectives: This study aimed to determine whether regional cerebral blood flow (rCBF) is abnormal in patients who have Transient Global Amnesia (TGA). Methods: We obtained noninvasive rCBF measurements using Tc-99m-ethyl cysteinate diamer Single Photon Emission Computed Tomography (SPECT) in 7 patients diagnosed with TGA within 4 days of onset of the amnestic episode while the patients were still symptomatic and in 17 age-matched healthy control subjects. We assessed memory functioning using the Hopkins's Verbal Learning Test (HVLT) and Statistical Parametric Mapping to compare rCBF across diagnostic groups. Results: The patients with TGA were significantly impaired in their performance on the 20-minute delayed recall of the HVLT. They also exhibited significantly decreased rCBF on their SPECT scans in the inferior and middle frontal gyrus bilaterally, with more prominent left-sided reductions in the superior temporal, precentral, and postcentral gyri, as well as increased rCBF primarily in the right hemisphere within the middle temporal, superior temporal, and inferior frontal gyri, cerebellum, and thalamus, compared with the normal control group. Conclusion: These findings suggest that lateralized abnormalities in brain functioning are an important component of the pathophysiology of TGA. Lateralized abnormalities may disrupt functions that are relatively specific to the left hemisphere, including receptive language, symbolic representation, and the processing of local features in the environment, while preserving anterograde memory processes. Increased flow to the right hemisphere centered on regions that subserve the functions of expressive language and visuospatial processing, and may represent processes that compensate for flow reductions to the left hemisphere. (C) 2008 Published by Elsevier Inc. | - |
dc.description.sponsorship | This work was supported by the Korean government (MOST) (No. R01-2007-000-21094-0 and No. M10644000028-06N4400-02810), NIMH grants MH59139, MH068318, K02-74677, the Suzanne Crosby Murphy Endowment at Columbia University College of Physicians and Surgeons, and the Thomas D. Klingenstein & Nancy D. Perlman Family Fund. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | TEMPORAL-LOBE | - |
dc.subject | HMPAO SPECT | - |
dc.subject | MEMORY | - |
dc.subject | PET | - |
dc.subject | HYPOPERFUSION | - |
dc.subject | IMPAIRMENT | - |
dc.subject | BRAIN | - |
dc.subject | LATERALIZATION | - |
dc.subject | ACETAZOLAMIDE | - |
dc.subject | HIPPOCAMPUS | - |
dc.title | A Tc-99m SPECT study of regional cerebral blood flow in patients with transient global amnesia | - |
dc.type | Article | - |
dc.identifier.wosid | 000266975300008 | - |
dc.identifier.scopusid | 2-s2.0-67349163708 | - |
dc.type.rims | ART | - |
dc.citation.volume | 47 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 50 | - |
dc.citation.endingpage | 55 | - |
dc.citation.publicationname | NEUROIMAGE | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Jeong, Jaeseung | - |
dc.contributor.nonIdAuthor | Chung, Yong An | - |
dc.contributor.nonIdAuthor | Yang, Dong Won | - |
dc.contributor.nonIdAuthor | Kang, Bong-Joo | - |
dc.contributor.nonIdAuthor | Kim, Sung Hoon | - |
dc.contributor.nonIdAuthor | Chung, Soo Kyo | - |
dc.contributor.nonIdAuthor | Sohn, Hyung Sun | - |
dc.contributor.nonIdAuthor | Peterson, Bradley S. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Transient global amnesia | - |
dc.subject.keywordAuthor | Brain perfusion SPECT | - |
dc.subject.keywordAuthor | Statistical parametric mapping | - |
dc.subject.keywordPlus | TEMPORAL-LOBE | - |
dc.subject.keywordPlus | HMPAO SPECT | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | PET | - |
dc.subject.keywordPlus | HYPOPERFUSION | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | LATERALIZATION | - |
dc.subject.keywordPlus | ACETAZOLAMIDE | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.