Toward Community Standards and Software for Whole-Cell Modeling

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dc.contributor.authorWaltemath, Dagmarko
dc.contributor.authorKarr, Jonathan Rko
dc.contributor.authorBergmann, Frank Tko
dc.contributor.authorLee, Daewonko
dc.contributor.authorSong, Je-Hoonko
dc.date.accessioned2016-11-09T06:58:53Z-
dc.date.available2016-11-09T06:58:53Z-
dc.date.created2016-10-31-
dc.date.created2016-10-31-
dc.date.issued2016-10-
dc.identifier.citationIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, v.63, no.10, pp.2007 - 2014-
dc.identifier.issn0018-9294-
dc.identifier.urihttp://hdl.handle.net/10203/213932-
dc.description.abstractObjective: Whole-cell (WC) modeling is a promising tool for biological research, bioengineering, and medicine. However, substantial work remains to create accurate comprehensive models of complex cells. Methods: We organized the 2015 Whole-Cell Modeling Summer School to teach WC modeling and evaluate the need for new WC modeling standards and software by recoding a recently published WC model in the Systems Biology Markup Language. Results: Our analysis revealed several challenges to representing WC models using the current standards. Conclusion: We, therefore, propose several new WC modeling standards, software, and databases. Significance: We anticipate that these new standards and software will enable more comprehensive models.-
dc.languageEnglish-
dc.publisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC-
dc.subjectMARKUP LANGUAGE SBML-
dc.subjectLEVEL 3-
dc.subjectSYSTEMS-
dc.subjectRECONSTRUCTION-
dc.subjectCONSTRAINTS-
dc.subjectSIMULATION-
dc.subjectMAPS-
dc.titleToward Community Standards and Software for Whole-Cell Modeling-
dc.typeArticle-
dc.identifier.wosid000384570200004-
dc.identifier.scopusid2-s2.0-84993897548-
dc.type.rimsART-
dc.citation.volume63-
dc.citation.issue10-
dc.citation.beginningpage2007-
dc.citation.endingpage2014-
dc.citation.publicationnameIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING-
dc.identifier.doi10.1109/TBME.2016.2560762-
dc.contributor.nonIdAuthorWaltemath, Dagmar-
dc.contributor.nonIdAuthorKarr, Jonathan R-
dc.contributor.nonIdAuthorBergmann, Frank T-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorComputational biology-
dc.subject.keywordAuthoreducation-
dc.subject.keywordAuthorsimulation-
dc.subject.keywordAuthorstandards-
dc.subject.keywordAuthorsystems biology-
dc.subject.keywordAuthorwhole-cell (WC) modeling-
dc.subject.keywordPlusMARKUP LANGUAGE SBML-
dc.subject.keywordPlusLEVEL 3-
dc.subject.keywordPlusSYSTEMS-
dc.subject.keywordPlusRECONSTRUCTION-
dc.subject.keywordPlusCONSTRAINTS-
dc.subject.keywordPlusSIMULATION-
dc.subject.keywordPlusMAPS-
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