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College of Natural Sciences(자연과학대학)Dept. of Chemistry(화학과)CH-Journal Papers(저널논문)

A bioorthogonal approach for imaging the binding between Dasatinib and its target proteins inside living cells

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dc.contributor.authorKim, Young-Rangko
dc.contributor.authorKim, Young Hyeko
dc.contributor.authorKim, Sung Wooko
dc.contributor.authorLee, Yong Juko
dc.contributor.authorChae, Dong-Eonko
dc.contributor.authorKim, Kyung-Ako
dc.contributor.authorLee, Zee-Wonko
dc.contributor.authorKim, Nam Dooko
dc.contributor.authorChoi, Jong-Soonko
dc.contributor.authorChoi, Insung S.ko
dc.contributor.authorLee, Kyung-Bokko
dc.date.accessioned2016-11-09T06:35:29Z-
dc.date.available2016-11-09T06:35:29Z-
dc.date.created2016-10-27-
dc.date.created2016-10-27-
dc.date.issued2016-07-
dc.identifier.citationCHEMICAL COMMUNICATIONS, v.52, no.79, pp.11764 - 11767-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10203/213916-
dc.description.abstractHerein, we present a simple readout of the binding between a chemical drug and its target proteins in the cytoplasm by using a two-step bioorthogonal labeling method combined with spatially-localized expression of proteins. Dasatinib was modified with transcyclooctene (TCO), and its cytoplasmic target kinases were expressed in intracellular compartments, such as endosomes and F-actins. After bioorthogonal labeling, the colocalization between Dasatinib and its target proteins was observed in intracellular compartments-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.subjectLIVE CELLS-
dc.subjectTRYPANOSOMA-BRUCEI-
dc.subjectFAMILY KINASES-
dc.subjectCHEMISTRY-
dc.subjectPROBES-
dc.subjectDRUG-
dc.subjectINHIBITION-
dc.subjectIMATINIB-
dc.subjectREVEAL-
dc.subjectDESIGN-
dc.titleA bioorthogonal approach for imaging the binding between Dasatinib and its target proteins inside living cells-
dc.typeArticle-
dc.identifier.wosid000384203700007-
dc.identifier.scopusid2-s2.0-84989960877-
dc.type.rimsART-
dc.citation.volume52-
dc.citation.issue79-
dc.citation.beginningpage11764-
dc.citation.endingpage11767-
dc.citation.publicationnameCHEMICAL COMMUNICATIONS-
dc.identifier.doi10.1039/c6cc07011f-
dc.contributor.localauthorChoi, Insung S.-
dc.contributor.nonIdAuthorKim, Young-Rang-
dc.contributor.nonIdAuthorKim, Young Hye-
dc.contributor.nonIdAuthorKim, Sung Woo-
dc.contributor.nonIdAuthorLee, Yong Ju-
dc.contributor.nonIdAuthorChae, Dong-Eon-
dc.contributor.nonIdAuthorKim, Kyung-A-
dc.contributor.nonIdAuthorLee, Zee-Won-
dc.contributor.nonIdAuthorKim, Nam Doo-
dc.contributor.nonIdAuthorChoi, Jong-Soon-
dc.contributor.nonIdAuthorLee, Kyung-Bok-
dc.type.journalArticleArticle-
dc.subject.keywordPlusLIVE CELLS-
dc.subject.keywordPlusTRYPANOSOMA-BRUCEI-
dc.subject.keywordPlusFAMILY KINASES-
dc.subject.keywordPlusCHEMISTRY-
dc.subject.keywordPlusPROBES-
dc.subject.keywordPlusDRUG-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusIMATINIB-
dc.subject.keywordPlusREVEAL-
dc.subject.keywordPlusDESIGN-
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CH-Journal Papers(저널논문)
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