DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yonghyun | ko |
dc.contributor.author | Lee, Soyoung | ko |
dc.contributor.author | Lee, Dong Yun | ko |
dc.contributor.author | Yu, Byeongjun | ko |
dc.contributor.author | Miao, Wenjun | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2016-11-09T05:34:21Z | - |
dc.date.available | 2016-11-09T05:34:21Z | - |
dc.date.created | 2016-10-19 | - |
dc.date.created | 2016-10-19 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.55, no.36, pp.10676 - 10680 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10203/213799 | - |
dc.description.abstract | Although stimuli-responsive materials hold potential for use as drug-delivery carriers for treating cancers, their clinical translation has been limited. Ideally, materials used for the purpose should be biocompatible and nontoxic, provide on-demand drug release in response to internal or external stimuli, allow large-scale manufacturing, and exhibit intrinsic anticancer efficacy. We present multistimuli-responsive nanoparticles formed from bilirubin, a potent endogenous antioxidant that possesses intrinsic anticancer and anti-inflammatory activity. Exposure of the bilirubin nanoparticles (BRNPs) to either reactive oxygen species (ROS) or external laser light causes rapid disruption of the BRNP nanostructure as a result of a switch in bilirubin solubility, thereby releasing encapsulated drugs. In a xenograft tumor model, BRNPs loaded with the anticancer drug doxorubicin (DOX@BRNPs), when combined with laser irradiation of 650nm, significantly inhibited tumor growth. This study suggests that BRNPs may be used as a drug-delivery carrier as well as a companion medicine for effectively treating cancers | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | SERUM BILIRUBIN | - |
dc.subject | CANCER | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | SYSTEMS | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | INHIBITION | - |
dc.subject | BILIVERDIN | - |
dc.subject | RELEASE | - |
dc.subject | POLYMER | - |
dc.title | Multistimuli-Responsive Bilirubin Nanoparticles for Anticancer Therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000383473600025 | - |
dc.identifier.scopusid | 2-s2.0-84980335855 | - |
dc.type.rims | ART | - |
dc.citation.volume | 55 | - |
dc.citation.issue | 36 | - |
dc.citation.beginningpage | 10676 | - |
dc.citation.endingpage | 10680 | - |
dc.citation.publicationname | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.identifier.doi | 10.1002/anie.201604858 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Lee, Yonghyun | - |
dc.contributor.nonIdAuthor | Lee, Soyoung | - |
dc.contributor.nonIdAuthor | Lee, Dong Yun | - |
dc.contributor.nonIdAuthor | Miao, Wenjun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | anticancer therapy | - |
dc.subject.keywordAuthor | bilirubin | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | nanomedicine | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | SERUM BILIRUBIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | BILIVERDIN | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | POLYMER | - |
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