DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Dae-Sik | ko |
dc.contributor.author | Han, Jeonghoon | ko |
dc.contributor.author | Won, Eun-Ji | ko |
dc.contributor.author | Kim, Duck-Hyun | ko |
dc.contributor.author | Jeong, Chang-Bum | ko |
dc.contributor.author | Hwang, Un-Ki | ko |
dc.contributor.author | Zhou, Bingsheng | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.contributor.author | Lee, Jae-Seong | ko |
dc.date.accessioned | 2016-10-07T09:29:22Z | - |
dc.date.available | 2016-10-07T09:29:22Z | - |
dc.date.created | 2016-10-05 | - |
dc.date.created | 2016-10-05 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | AQUATIC TOXICOLOGY, v.177, pp.285 - 294 | - |
dc.identifier.issn | 0166-445X | - |
dc.identifier.uri | http://hdl.handle.net/10203/213238 | - |
dc.description.abstract | 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is a persistent organic pollutant (POP) in marine environments. Despite its adverse effects (e.g. developmental retardation) in ecdysozoa, the effects of BDE-47 on transcription of ecdysteroid signaling pathway-involved-nuclear receptor (NR) genes and metamorphosis-related genes have not been examined in copepods. To examine the deleterious effect of BDE-47 on copepod molting and metamorphosis, BDE-47 was exposed to the harpacticoid copepod Tigri-opus japonicus, followed by monitoring developmental retardation and transcriptional alteration of NR genes. The developmental rate was significantly inhibited (P< 0.05) in response to BDE-47 and the agricultural insecticide gamma-hexachlorocyclohexane. Conversely, the ecdysteroid agonist ponasterone A (PoA) led to decreased molting and metamorphosis time (P< 0.05) from the nauplius stage to the adult stage. In particular, expression profiles of all NR genes were the highest at naupliar stages 5-6 except for SVP, FTZ-F1, and HR96 genes. Nuclear receptor USP, HR96, and FTZ-F1 genes also showed significant sex differences (P< 0.05) in gene expression levels over different developmental stages, indicating that these genes may be involved in vitellogenesis. NR gene expression patterns showed significant decreases (P< 0.05)in response to BDE-47 exposure, implying that molting and metamorphosis retardation is likely associated with NR gene expression. In summary, BDE-47 leads to molting and metamorphosis retardation and suppresses transcription of NR genes. This information will be helpful in understanding the molting and metamorphosis delay mechanism in response to BDE-47 exposure. (C) 2016 Elsevier B.V. All rights reserved | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | POLYBROMINATED DIPHENYL ETHERS | - |
dc.subject | BROMINATED FLAME RETARDANTS | - |
dc.subject | HARPACTICOID COPEPOD | - |
dc.subject | ECDYSONE RECEPTOR | - |
dc.subject | NITOCRA-SPINIPES | - |
dc.subject | AEDES-AEGYPTI | - |
dc.subject | DROSOPHILA | - |
dc.subject | REPRODUCTION | - |
dc.subject | MOSQUITO | - |
dc.subject | GROWTH | - |
dc.title | BDE-47 causes developmental retardation with down-regulated expression profiles of ecdysteroid signaling pathway-involved nuclear receptor (NR) genes in the copepod Tigriopus japonicus | - |
dc.type | Article | - |
dc.identifier.wosid | 000381529700028 | - |
dc.identifier.scopusid | 2-s2.0-84975516194 | - |
dc.type.rims | ART | - |
dc.citation.volume | 177 | - |
dc.citation.beginningpage | 285 | - |
dc.citation.endingpage | 294 | - |
dc.citation.publicationname | AQUATIC TOXICOLOGY | - |
dc.identifier.doi | 10.1016/j.aquatox.2016.06.004 | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Hwang, Dae-Sik | - |
dc.contributor.nonIdAuthor | Han, Jeonghoon | - |
dc.contributor.nonIdAuthor | Won, Eun-Ji | - |
dc.contributor.nonIdAuthor | Kim, Duck-Hyun | - |
dc.contributor.nonIdAuthor | Jeong, Chang-Bum | - |
dc.contributor.nonIdAuthor | Hwang, Un-Ki | - |
dc.contributor.nonIdAuthor | Zhou, Bingsheng | - |
dc.contributor.nonIdAuthor | Lee, Jae-Seong | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | BDE-47 | - |
dc.subject.keywordAuthor | Molting | - |
dc.subject.keywordAuthor | Metamorphosis | - |
dc.subject.keywordAuthor | Ecdysteroid signaling pathway | - |
dc.subject.keywordAuthor | Nuclear receptor | - |
dc.subject.keywordAuthor | Copepod Tigriopus japonicus | - |
dc.subject.keywordPlus | POLYBROMINATED DIPHENYL ETHERS | - |
dc.subject.keywordPlus | BROMINATED FLAME RETARDANTS | - |
dc.subject.keywordPlus | HARPACTICOID COPEPOD | - |
dc.subject.keywordPlus | ECDYSONE RECEPTOR | - |
dc.subject.keywordPlus | NITOCRA-SPINIPES | - |
dc.subject.keywordPlus | AEDES-AEGYPTI | - |
dc.subject.keywordPlus | REPRODUCTION | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | MOSQUITO | - |
dc.subject.keywordPlus | GROWTH | - |
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