DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Yoonjee | ko |
dc.contributor.author | Cha, Junghwa | ko |
dc.contributor.author | Kang, Seok-Gu | ko |
dc.contributor.author | Kim, Pilnam | ko |
dc.date.accessioned | 2016-10-04T07:12:33Z | - |
dc.date.available | 2016-10-04T07:12:33Z | - |
dc.date.created | 2016-09-12 | - |
dc.date.created | 2016-09-12 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.39, pp.10 - 15 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | http://hdl.handle.net/10203/213044 | - |
dc.description.abstract | We report a formation of macroporous scaffold which is based on polyethylene glycol (PEG)-based alginate (ALG) interpenetrating polymer network (IPN) hydrogel. Using this scaffold, we assess the tumorsphere (TS)-forming ability of glioma cancer stem cells (gCSCs), which subpopulation has been highlighted as a main cause of therapeutic resistance due to self-renewal and potential of differentiation properties. Although there have been numerous methods to study the TSs, however, there is no plausible method to evaluate the formation of single gCSC cell-derived TSs, due to fusion-induced cell aggregation. To provide reliable assessment, the PEGDA hydrogel interpenetrated with ALG was fabricated as macroporous scaffold for TS formation of patient-derived gCSCs. With UV-ionic dual crosslinking process, the pore size ofPEGDA-ALG hydrogel is magnified enough to be applied as a macroporous scaffold, providing increased internal voids for TS growth and expansion. As a result, within macroporous scaffold, the multiple number of single gCSC-derived TSs was successfully formed inside the structural voids. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | TUMOR-INITIATING CELLS | - |
dc.subject | CANCER STEM-CELLS | - |
dc.subject | PEG HYDROGELS | - |
dc.subject | MASS-TRANSFER | - |
dc.subject | NETWORKS | - |
dc.subject | ALGINATE | - |
dc.subject | ENCAPSULATION | - |
dc.subject | MICROSPHERES | - |
dc.subject | PROGENITOR | - |
dc.subject | CULTURE | - |
dc.title | A polyethylene glycol-based hydrogel as macroporous scaffold for tumorsphere formation of glioblastoma multiforme | - |
dc.type | Article | - |
dc.identifier.wosid | 000380622300002 | - |
dc.identifier.scopusid | 2-s2.0-84990895404 | - |
dc.type.rims | ART | - |
dc.citation.volume | 39 | - |
dc.citation.beginningpage | 10 | - |
dc.citation.endingpage | 15 | - |
dc.citation.publicationname | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.identifier.doi | 10.1016/j.jiec.2016.05.012 | - |
dc.contributor.localauthor | Kim, Pilnam | - |
dc.contributor.nonIdAuthor | Oh, Yoonjee | - |
dc.contributor.nonIdAuthor | Kang, Seok-Gu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Polyethylene glycol | - |
dc.subject.keywordAuthor | Macroporous hydrogel | - |
dc.subject.keywordAuthor | Tumorsphere | - |
dc.subject.keywordAuthor | Glioblastoma multiform | - |
dc.subject.keywordPlus | TUMOR-INITIATING CELLS | - |
dc.subject.keywordPlus | CANCER STEM-CELLS | - |
dc.subject.keywordPlus | PEG HYDROGELS | - |
dc.subject.keywordPlus | MASS-TRANSFER | - |
dc.subject.keywordPlus | NETWORKS | - |
dc.subject.keywordPlus | ALGINATE | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | PROGENITOR | - |
dc.subject.keywordPlus | CULTURE | - |
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