The KEK to Kamioka long-baseline neutrino experiment (K2K) has begun its investigation of neutrino oscillations suggested by atmospheric neutrino observations. Twenty-eight neutrino events have been detected in coincidence with the expected arrival time of the beam in the 22.5 kt fiducial volume of Super-Kamiokande, the far detector at 250 km distance. The expectation is 37.8(-3.8)(+3.5), derived using measurements of neutrino interactions in a near detector and extrapolation using a beam simulation validated by a measurement of pion kinematics after production and focusing. The background is of order 10(-3) events. (C) 2001 Published by Elsevier Science B.V.