DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yoosik | ko |
dc.contributor.author | Jose Andreu, Maria | ko |
dc.contributor.author | Lim, Bomyi | ko |
dc.contributor.author | Chung, Kwanghun | ko |
dc.contributor.author | Terayama, Mark | ko |
dc.contributor.author | Jimenez, Gerardo | ko |
dc.contributor.author | Berg, Celeste A. | ko |
dc.contributor.author | Lu, Hang | ko |
dc.contributor.author | Shvartsman, Stanislav Y. | ko |
dc.date.accessioned | 2016-07-25T07:50:40Z | - |
dc.date.available | 2016-07-25T07:50:40Z | - |
dc.date.created | 2016-02-01 | - |
dc.date.created | 2016-02-01 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.citation | DEVELOPMENTAL CELL, v.20, no.6, pp.880 - 887 | - |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.uri | http://hdl.handle.net/10203/211824 | - |
dc.description.abstract | Developing tissues are patterned by coordinated activities of signaling systems, which can be integrated by a regulatory region of a gene that binds multiple transcription factors or by a transcription factor that is modified by multiple enzymes. Based on a combination of genetic and imaging experiments in the early Drosophila embryo, we describe a signal integration mechanism that cannot be reduced to a single gene regulatory element or a single transcription factor. This mechanism relies on an enzymatic network formed by mitogen-activated protein kinase (MAPK) and its substrates. Specifically, anteriorly localized MAPK substrates, such as Bicoid, antagonize MAPK-dependent down-regulation of Capicua, a repressor that is involved in gene regulation along the dorsoventral axis of the embryo. MAPK substrate competition provides a basis for ternary interaction of the anterior, dorsoventral, and terminal patterning systems. A mathematical model of this interaction can explain gene expression patterns with both anteroposterior and dorsoventral polarities. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | DROSOPHILA-EMBRYO | - |
dc.subject | DORSAL MORPHOGEN | - |
dc.subject | SIGNALING SPECIFICITY | - |
dc.subject | TERMINAL SYSTEM | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | TORSO | - |
dc.subject | EXPRESSION | - |
dc.subject | PROTEIN | - |
dc.subject | PATTERN | - |
dc.subject | CAPICUA | - |
dc.title | Gene Regulation by MAPK Substrate Competition | - |
dc.type | Article | - |
dc.identifier.wosid | 000291763500015 | - |
dc.identifier.scopusid | 2-s2.0-79958195843 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 880 | - |
dc.citation.endingpage | 887 | - |
dc.citation.publicationname | DEVELOPMENTAL CELL | - |
dc.identifier.doi | 10.1016/j.devcel.2011.05.009 | - |
dc.contributor.localauthor | Kim, Yoosik | - |
dc.contributor.nonIdAuthor | Jose Andreu, Maria | - |
dc.contributor.nonIdAuthor | Lim, Bomyi | - |
dc.contributor.nonIdAuthor | Chung, Kwanghun | - |
dc.contributor.nonIdAuthor | Terayama, Mark | - |
dc.contributor.nonIdAuthor | Jimenez, Gerardo | - |
dc.contributor.nonIdAuthor | Berg, Celeste A. | - |
dc.contributor.nonIdAuthor | Lu, Hang | - |
dc.contributor.nonIdAuthor | Shvartsman, Stanislav Y. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DROSOPHILA-EMBRYO | - |
dc.subject.keywordPlus | DORSAL MORPHOGEN | - |
dc.subject.keywordPlus | SIGNALING SPECIFICITY | - |
dc.subject.keywordPlus | TERMINAL SYSTEM | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | TORSO | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PATTERN | - |
dc.subject.keywordPlus | CAPICUA | - |
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