DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Jun Hyuk | ko |
dc.contributor.author | Lee, Ho-Sung | ko |
dc.contributor.author | Kang, Yun Won | ko |
dc.contributor.author | Cho, Kwang-Hyun | ko |
dc.date.accessioned | 2016-07-07T07:01:40Z | - |
dc.date.available | 2016-07-07T07:01:40Z | - |
dc.date.created | 2016-01-06 | - |
dc.date.created | 2016-01-06 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | BRIEFINGS IN BIOINFORMATICS, v.17, no.3, pp.419 - 428 | - |
dc.identifier.issn | 1467-5463 | - |
dc.identifier.uri | http://hdl.handle.net/10203/210189 | - |
dc.description.abstract | Recent systems biological studies of cardiac systems have greatly advanced our understanding of cardiac physiology with a particular focus on the excitation-contraction coupling. With these advancements, there is a growing interest in systems analysis of the cardiac signaling network because its dynamical property is closely associated with cardiac diseases. In this article, we review recent attempts at computational modeling of the cardiac signaling network and provide a system-level perspective on the analysis of the large-scale cardiac signaling network. We discuss why the systems biological approach is useful and what novel insights it can provide for the development of personalized therapeutic strategies for cardiac diseases in the post-genomic era. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | PHOSPHOINOSITIDE 3-KINASE PATHWAY | - |
dc.subject | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject | DIASTOLIC HEART-FAILURE | - |
dc.subject | N-TERMINAL KINASES | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | IN-VIVO | - |
dc.subject | CALCINEURIN ACTIVITY | - |
dc.subject | BETA(2)-ADRENERGIC RECEPTOR | - |
dc.subject | BETA(1)-ADRENERGIC RECEPTOR | - |
dc.subject | PERSONALIZED MEDICINE | - |
dc.title | Systems biological approaches to the cardiac signaling network | - |
dc.type | Article | - |
dc.identifier.wosid | 000377464300006 | - |
dc.identifier.scopusid | 2-s2.0-84971612145 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 419 | - |
dc.citation.endingpage | 428 | - |
dc.citation.publicationname | BRIEFINGS IN BIOINFORMATICS | - |
dc.identifier.doi | 10.1093/bib/bbv039 | - |
dc.contributor.localauthor | Cho, Kwang-Hyun | - |
dc.contributor.nonIdAuthor | Kang, Yun Won | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cardiac signaling network | - |
dc.subject.keywordAuthor | heart failure | - |
dc.subject.keywordAuthor | mathematical modeling | - |
dc.subject.keywordAuthor | molecular dynamics analysis | - |
dc.subject.keywordAuthor | personalized therapy | - |
dc.subject.keywordAuthor | systems biology | - |
dc.subject.keywordPlus | PHOSPHOINOSITIDE 3-KINASE PATHWAY | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | DIASTOLIC HEART-FAILURE | - |
dc.subject.keywordPlus | N-TERMINAL KINASES | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CALCINEURIN ACTIVITY | - |
dc.subject.keywordPlus | BETA(2)-ADRENERGIC RECEPTOR | - |
dc.subject.keywordPlus | BETA(1)-ADRENERGIC RECEPTOR | - |
dc.subject.keywordPlus | PERSONALIZED MEDICINE | - |
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