DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Hyung-Joon | ko |
dc.contributor.author | Choi, Go-Eun | ko |
dc.contributor.author | Ryu, Sangryeol | ko |
dc.contributor.author | Kwon, Soon Jae | ko |
dc.contributor.author | Kim, Sun Chang | ko |
dc.contributor.author | Booth, Claire | ko |
dc.contributor.author | Nichols, Kim E. | ko |
dc.contributor.author | Kim, Hun Sik | ko |
dc.date.accessioned | 2016-07-07T05:36:52Z | - |
dc.date.available | 2016-07-07T05:36:52Z | - |
dc.date.created | 2016-06-21 | - |
dc.date.created | 2016-06-21 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.7 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/209834 | - |
dc.description.abstract | NF-kappa B is a key transcription factor that dictates the outcome of diverse immune responses. How NF-kappa B is regulated by multiple activating receptors that are engaged during natural killer (NK)-target cell contact remains undefined. Here we show that sole engagement of NKG2D, 2B4 or DNAM-1 is insufficient for NF-kappa B activation. Rather, cooperation between these receptors is required at the level of Vav1 for synergistic NF-kappa B activation. Vav1-dependent synergistic signalling requires a separate PI3K-Akt signal, primarily mediated by NKG2D or DNAM-1, for optimal p65 phosphorylation and NF-kappa B activation. Vav1 controls downstream p65 phosphorylation and NF-kappa B activation. Synergistic signalling is defective in X-linked lymphoproliferative disease (XLP1) NK cells entailing 2B4 dysfunction and required for p65 phosphorylation by PI3K-Akt signal, suggesting stepwise signalling checkpoint for NF-kappa B activation. Thus, our study provides a framework explaining how signals from different activating receptors are coordinated to determine specificity and magnitude of NF-kappa B activation and NK cell responses | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NATURAL-KILLER-CELLS | - |
dc.subject | LINKED LYMPHOPROLIFERATIVE-DISEASE | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | ENCODING GENE | - |
dc.subject | EBV INFECTION | - |
dc.subject | CUTTING EDGE | - |
dc.subject | ADAPTER SAP | - |
dc.subject | CYTOKINE | - |
dc.subject | CYTOTOXICITY | - |
dc.title | Stepwise phosphorylation of p65 promotes NF-kappa B activation and NK cell responses during target cell recognition | - |
dc.type | Article | - |
dc.identifier.wosid | 000376669600001 | - |
dc.identifier.scopusid | 2-s2.0-84971325230 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms11686 | - |
dc.contributor.localauthor | Kim, Sun Chang | - |
dc.contributor.nonIdAuthor | Kwon, Hyung-Joon | - |
dc.contributor.nonIdAuthor | Choi, Go-Eun | - |
dc.contributor.nonIdAuthor | Ryu, Sangryeol | - |
dc.contributor.nonIdAuthor | Kwon, Soon Jae | - |
dc.contributor.nonIdAuthor | Booth, Claire | - |
dc.contributor.nonIdAuthor | Nichols, Kim E. | - |
dc.contributor.nonIdAuthor | Kim, Hun Sik | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | LINKED LYMPHOPROLIFERATIVE-DISEASE | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ENCODING GENE | - |
dc.subject.keywordPlus | EBV INFECTION | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | ADAPTER SAP | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
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