DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leon, J. Christian | ko |
dc.contributor.author | Sinha, Indranil | ko |
dc.contributor.author | Mueller, Jens | ko |
dc.date.accessioned | 2016-07-06T04:24:17Z | - |
dc.date.available | 2016-07-06T04:24:17Z | - |
dc.date.created | 2016-06-08 | - |
dc.date.created | 2016-06-08 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.17, no.4 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/10203/209537 | - |
dc.description.abstract | The artificial nucleobase 6-pyrazol-1-yl-purine (6PP) has been investigated with respect to its usability in metal-mediated base pairing. As was shown by temperature-dependent UV spectroscopy, 6PP may form weakly stabilizing 6PP-Ag(I)-6PP homo base pairs. Interestingly, 6PP can be used to selectively recognize a complementary pyrimidine nucleobase. The addition of Ag(I) to a DNA duplex comprising a central 6PP: C mispair (C = cytosine) leads to a slight destabilization of the duplex. In contrast, a stabilizing 6PP-Ag(I)-T base pair is formed with a complementary thymine (T) residue. It is interesting to note that 6PP is capable of differentiating between the pyrimidine moieties despite the fact that it is not as sterically crowded as 6-(3,5-dimethylpyrazol-1-yl) purine, an artificial nucleobase that had previously been suggested for the recognition of nucleic acid sequences via the formation of a metal-mediated base pair. Hence, the additional methyl groups of 6-(3,5-dimethylpyrazol-1-yl) purine may not be required for the specific recognition of the complementary nucleobase | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.subject | HG-II-T | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | PURINES | - |
dc.subject | NUCLEOSIDES | - |
dc.subject | COMPLEXES | - |
dc.subject | PARALLEL | - |
dc.subject | IONS | - |
dc.title | 6-Pyrazolylpurine as an Artificial Nucleobase for Metal-Mediated Base Pairing in DNA Duplexes | - |
dc.type | Article | - |
dc.identifier.wosid | 000374585300133 | - |
dc.identifier.scopusid | 2-s2.0-84963752219 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 4 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.identifier.doi | 10.3390/ijms17040554 | - |
dc.contributor.nonIdAuthor | Leon, J. Christian | - |
dc.contributor.nonIdAuthor | Mueller, Jens | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cytosine | - |
dc.subject.keywordAuthor | metal-mediated base pair | - |
dc.subject.keywordAuthor | purine | - |
dc.subject.keywordAuthor | thymine | - |
dc.subject.keywordPlus | HG-II-T | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | PURINES | - |
dc.subject.keywordPlus | NUCLEOSIDES | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | PARALLEL | - |
dc.subject.keywordPlus | IONS | - |
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