DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Chanil | ko |
dc.contributor.author | Kim, Juin | ko |
dc.contributor.author | Jeong, Hawoong | ko |
dc.contributor.author | Jung, Youngkyun | ko |
dc.contributor.author | Ha, Bae-Yeun | ko |
dc.date.accessioned | 2016-05-12T03:00:06Z | - |
dc.date.available | 2016-05-12T03:00:06Z | - |
dc.date.created | 2015-11-30 | - |
dc.date.created | 2015-11-30 | - |
dc.date.created | 2015-11-30 | - |
dc.date.created | 2015-11-30 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | SOFT MATTER, v.11, no.41, pp.8179 - 8193 | - |
dc.identifier.issn | 1744-683X | - |
dc.identifier.uri | http://hdl.handle.net/10203/207193 | - |
dc.description.abstract | To what extent does a confined polymer show chromosome-like organization? Using molecular dynamics simulations, we study a model Escherichia coli (E. coli) chromosome: an asymmetrical ring polymer, formed by small monomers on one side and big monomers on the other confined in a concentric-shell or simple cylinder with closed ends. The ring polymer is organized in the way observed for the E. coli chromosome: if the big monomers are assumed to be localized in the inner cylinder, the two "subchains" forming the ring are spontaneously partitioned in a parallel orientation with the "body" (big-monomer) chain linearly organized with a desired precision and the crossing (small-monomer) chain residing preferentially in the peripheral region. Furthermore, we show that the introduction of a "fluctuating boundary" between the two subchains leads to a double-peak distribution of ter-proximate loci, as seen in experiments, which would otherwise remain single-peaked. In a simple cylinder, however, a chromosome-like organization of the ring polymer typically requires an external mechanism such as cell-wall attachment. Finally, our results clarify to what degree the spatial organization of the chromosomes can be accomplished solely by ring asymmetry and anisotropic confinement. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Chromosome-like organization of an asymmetrical ring polymer confined in a cylindrical space | - |
dc.type | Article | - |
dc.identifier.wosid | 000363204000016 | - |
dc.identifier.scopusid | 2-s2.0-84944338791 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 41 | - |
dc.citation.beginningpage | 8179 | - |
dc.citation.endingpage | 8193 | - |
dc.citation.publicationname | SOFT MATTER | - |
dc.identifier.doi | 10.1039/c5sm01286d | - |
dc.contributor.localauthor | Jeong, Hawoong | - |
dc.contributor.nonIdAuthor | Jeon, Chanil | - |
dc.contributor.nonIdAuthor | Jung, Youngkyun | - |
dc.contributor.nonIdAuthor | Ha, Bae-Yeun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI CHROMOSOME | - |
dc.subject.keywordPlus | MOLECULAR-DYNAMICS SIMULATION | - |
dc.subject.keywordPlus | BACTERIAL CHROMOSOME | - |
dc.subject.keywordPlus | SEGREGATION | - |
dc.subject.keywordPlus | ARCHITECTURE | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | MACRODOMAIN | - |
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