DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ju, Young Seok | ko |
dc.contributor.author | Kim, Jong Il | ko |
dc.contributor.author | Kim, Shee Hyun | ko |
dc.contributor.author | Hong, Dong Wan | ko |
dc.contributor.author | Park, Han Soo | ko |
dc.contributor.author | Shin, Jong Yeon | ko |
dc.contributor.author | Lee, Seung Bok | ko |
dc.contributor.author | Lee, Won Chul | ko |
dc.contributor.author | Kim, Su Jung | ko |
dc.contributor.author | Yu, Saet Byeol | ko |
dc.contributor.author | Park, Sung Soo | ko |
dc.contributor.author | Seo, Seung Hyun | ko |
dc.contributor.author | Yun, Ji Young | ko |
dc.contributor.author | Kim, Hyun Jin | ko |
dc.contributor.author | Lee, Dong Sung | ko |
dc.contributor.author | Yavartanoo, Maryam | ko |
dc.contributor.author | Kang, Hyunseok Peter | ko |
dc.contributor.author | Gokcumen, Omer | ko |
dc.contributor.author | Govindaraju, Diddahally R. | ko |
dc.contributor.author | Jung, Jung Hee | ko |
dc.contributor.author | Chong, Hyonyong | ko |
dc.contributor.author | Yang, Kap Seok | ko |
dc.contributor.author | Kim, Hyung Tae | ko |
dc.contributor.author | Lee, Charles | ko |
dc.contributor.author | Seo, Jeong Sun | ko |
dc.date.accessioned | 2016-05-10T08:24:04Z | - |
dc.date.available | 2016-05-10T08:24:04Z | - |
dc.date.created | 2015-12-09 | - |
dc.date.created | 2015-12-09 | - |
dc.date.created | 2015-12-09 | - |
dc.date.issued | 2011-08 | - |
dc.identifier.citation | NATURE GENETICS, v.43, no.8, pp.745 - 752 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://hdl.handle.net/10203/207086 | - |
dc.description.abstract | Massively parallel sequencing technologies have identified a broad spectrum of human genome diversity. Here we deep sequenced and correlated 18 genomes and 17 transcriptomes of unrelated Korean individuals. This has allowed us to construct a genome-wide map of common and rare variants and also identify variants formed during DNA-RNA transcription. We identified 9.56 million genomic variants, 23.2% of which appear to be previously unidentified. From transcriptome sequencing, we discovered 4,414 transcripts not previously annotated. Finally, we revealed 1,809 sites of transcriptional base modification, where the transcriptional landscape is different from the corresponding genomic sequences, and 580 sites of allele-specific expression. Our findings suggest that a considerable number of unexplored genomic variants still remain to be identified in the human genome, and that the integrated analysis of genome and transcriptome sequencing is powerful for understanding the diversity and functional aspects of human genomic variants. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Extensive genomic and transcriptional diversity identified through massively parallel DNA and RNA sequencing of eighteen Korean individuals | - |
dc.type | Article | - |
dc.identifier.wosid | 000293178300010 | - |
dc.identifier.scopusid | 2-s2.0-79960914208 | - |
dc.type.rims | ART | - |
dc.citation.volume | 43 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 745 | - |
dc.citation.endingpage | 752 | - |
dc.citation.publicationname | NATURE GENETICS | - |
dc.identifier.doi | 10.1038/ng.872 | - |
dc.contributor.localauthor | Ju, Young Seok | - |
dc.contributor.nonIdAuthor | Kim, Jong Il | - |
dc.contributor.nonIdAuthor | Kim, Shee Hyun | - |
dc.contributor.nonIdAuthor | Hong, Dong Wan | - |
dc.contributor.nonIdAuthor | Park, Han Soo | - |
dc.contributor.nonIdAuthor | Shin, Jong Yeon | - |
dc.contributor.nonIdAuthor | Lee, Seung Bok | - |
dc.contributor.nonIdAuthor | Lee, Won Chul | - |
dc.contributor.nonIdAuthor | Kim, Su Jung | - |
dc.contributor.nonIdAuthor | Yu, Saet Byeol | - |
dc.contributor.nonIdAuthor | Park, Sung Soo | - |
dc.contributor.nonIdAuthor | Seo, Seung Hyun | - |
dc.contributor.nonIdAuthor | Yun, Ji Young | - |
dc.contributor.nonIdAuthor | Kim, Hyun Jin | - |
dc.contributor.nonIdAuthor | Lee, Dong Sung | - |
dc.contributor.nonIdAuthor | Yavartanoo, Maryam | - |
dc.contributor.nonIdAuthor | Kang, Hyunseok Peter | - |
dc.contributor.nonIdAuthor | Gokcumen, Omer | - |
dc.contributor.nonIdAuthor | Govindaraju, Diddahally R. | - |
dc.contributor.nonIdAuthor | Jung, Jung Hee | - |
dc.contributor.nonIdAuthor | Chong, Hyonyong | - |
dc.contributor.nonIdAuthor | Yang, Kap Seok | - |
dc.contributor.nonIdAuthor | Kim, Hyung Tae | - |
dc.contributor.nonIdAuthor | Lee, Charles | - |
dc.contributor.nonIdAuthor | Seo, Jeong Sun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | STRUCTURAL VARIANTS | - |
dc.subject.keywordPlus | EDITING SITES | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | COMMON | - |
dc.subject.keywordPlus | READS | - |
dc.subject.keywordPlus | SNP | - |
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