DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Won Suck | ko |
dc.contributor.author | Kim, EJ | ko |
dc.contributor.author | Lee, I | ko |
dc.contributor.author | Kim, SG | ko |
dc.contributor.author | Lee, MG | ko |
dc.contributor.author | Kim, SH | ko |
dc.date.accessioned | 2016-04-22T08:33:19Z | - |
dc.date.available | 2016-04-22T08:33:19Z | - |
dc.date.created | 2016-01-29 | - |
dc.date.created | 2016-01-29 | - |
dc.date.issued | 2003-06 | - |
dc.identifier.citation | LIFE SCIENCES, v.73, no.3, pp.253 - 263 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | http://hdl.handle.net/10203/206036 | - |
dc.description.abstract | It has been reported from our laboratories that expression of CYP2E1 significantly increased and decreased in rats with acute renal failure induced by uranyl nitrate (U-ARF) treated with recombinant human growth hormone (rGH) for one day (U-ARF1) compared with those in control rats and rats with U-ARF, respectively. Chlorzoxazone (CZX) primarily undergoes hydroxylation to form 6-hydroxychlorzoxazone (OH-CZX) catalyzed mainly by CYP2E1 in rats. Hence, the effects of rGH on the pharmacokinetics of intravenous CZX (20 mg/kg) were investigated in rats with U-ARF. Based on CYP2E1 expression, it could be expected that in rats with U-ARF1, the formation of OH-CZX significantly increased and decreased compared with those in control rats and rats with U-ARF, respectively. This was proven in the following results. First, the total area under the plasma concentration-time curve from time zero to 8 hr (AUC(0-->8 hr)) of OH-CZX in rats with U-ARF1 (36100 mug min/ml) was significantly greater and smaller than those in control rats (1040 mug min/ml) and rats with U-ARF (50300 mug min/ml), respectively. Second, the AUC(0-->8 hr), (OH-CZX)/AUC(CZX) ratio in rats with U-ARF1 (28.9) was significantly greater and smaller than those in control rats (0.468) and rats with U-ARF (72.6), respectively. (C) 2003 Elsevier Science Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PROTEIN-CALORIE MALNUTRITION | - |
dc.subject | CYTOCHROME-P450 2E1 | - |
dc.subject | DOSAGE REGIMENS | - |
dc.subject | PLASMA | - |
dc.subject | 6-HYDROXYCHLORZOXAZONE | - |
dc.subject | HYDROXYLATION | - |
dc.subject | METABOLISM | - |
dc.subject | CLEARANCE | - |
dc.subject | BINDING | - |
dc.subject | DRUGS | - |
dc.title | Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate | - |
dc.type | Article | - |
dc.identifier.wosid | 000183114000001 | - |
dc.type.rims | ART | - |
dc.citation.volume | 73 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 253 | - |
dc.citation.endingpage | 263 | - |
dc.citation.publicationname | LIFE SCIENCES | - |
dc.identifier.doi | 10.1016/S0024-3205(03)00268-6 | - |
dc.contributor.localauthor | Chung, Won Suck | - |
dc.contributor.nonIdAuthor | Kim, EJ | - |
dc.contributor.nonIdAuthor | Lee, I | - |
dc.contributor.nonIdAuthor | Kim, SG | - |
dc.contributor.nonIdAuthor | Lee, MG | - |
dc.contributor.nonIdAuthor | Kim, SH | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | CYP2E1 | - |
dc.subject.keywordAuthor | chlorzoxazone | - |
dc.subject.keywordAuthor | 6-hydroxychlorzoxazone | - |
dc.subject.keywordAuthor | rGH | - |
dc.subject.keywordAuthor | U-ARF | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordPlus | PROTEIN-CALORIE MALNUTRITION | - |
dc.subject.keywordPlus | CYTOCHROME-P450 2E1 | - |
dc.subject.keywordPlus | DOSAGE REGIMENS | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | 6-HYDROXYCHLORZOXAZONE | - |
dc.subject.keywordPlus | HYDROXYLATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DRUGS | - |
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