DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, SK | ko |
dc.contributor.author | Chung, WS | ko |
dc.contributor.author | Kim, EJ | ko |
dc.contributor.author | Rhee, JK | ko |
dc.contributor.author | Kwon, JW | ko |
dc.contributor.author | Kim, WB | ko |
dc.contributor.author | Lee, MG | ko |
dc.date.accessioned | 2016-04-22T08:33:07Z | - |
dc.date.available | 2016-04-22T08:33:07Z | - |
dc.date.created | 2016-01-29 | - |
dc.date.created | 2016-01-29 | - |
dc.date.issued | 2004-04 | - |
dc.identifier.citation | BIOPHARMACEUTICS & DRUG DISPOSITION, v.25, no.3, pp.127 - 135 | - |
dc.identifier.issn | 0142-2782 | - |
dc.identifier.uri | http://hdl.handle.net/10203/206034 | - |
dc.description.abstract | The pharmacokinetics after single intravenous and single and consecutive 2 week oral administration, tissue distribution, in vitro tissue metabolism, stability, blood partition and protein binding of DA-7867, a new oxazolidinone, were evaluated. After intravenous administration at a dose of 10 mg/kg to rats, DA-7867 was eliminated slowly with time-averaged total body clearance of 0.915 ml/min/kg. After consecutive 2 week oral administration at a dose of 2 mg/kg/day to rats, DA-7867 was accumulated in rats; the AUC was significantly greater (1430 versus 1880 mug min/ml) than that after single oral administration at a dose of 2mg/kg. The rat tissues studied had low affinity to DA-7867; the tissue-to-plasma ratios were smaller than unity after both intravenous and oral administration at a dose of 20 mg/kg. The rat tissues studied had almost negligible metabolic activity for DA-7867 based on 30 min incubation of DA-7867 with 9000g supernatant fraction of rat tissues. DA-7867 was stable for up to 24 h incubation in various buffer solutions having pHs from I to 11, Sorensen phosphate buffer of pH 7.4, and rat plasma, urine and liver homogenate and 3 h incubation in five human gastric juices. The binding of DA-7867 to 4% human serum albumin was 50.6% at DA-7867 concentrations ranging from 0.5 to 20mug/ml. The equilibrium of DA-7867 between plasma and blood cells of rabbit blood reached fast (within 30 s manual mixing), and the plasma-to-blood cell concentration ratios were independent of initial blood concentrations of DA-7867, 1-20 mug/ml; the values ranged from 1.39 to 1.63. Protein binding of DA-7867 in five fresh rats plasma was 72.3%. Copyright (C) 2004 John Wiley Sons, Ltd. | - |
dc.language | English | - |
dc.publisher | JOHN WILEY & SONS LTD | - |
dc.subject | ISOLATED RAT-LIVER | - |
dc.subject | DRUG ELIMINATION | - |
dc.subject | DOSAGE REGIMENS | - |
dc.subject | PLASMA | - |
dc.subject | ERYTHROCYTES | - |
dc.subject | METABOLISM | - |
dc.subject | STABILITY | - |
dc.subject | BARRIERS | - |
dc.subject | AGENT | - |
dc.title | Pharmacokinetics, blood partition and protein binding of DA-7867, a new oxazolidinone | - |
dc.type | Article | - |
dc.identifier.wosid | 000221127400004 | - |
dc.type.rims | ART | - |
dc.citation.volume | 25 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 127 | - |
dc.citation.endingpage | 135 | - |
dc.citation.publicationname | BIOPHARMACEUTICS & DRUG DISPOSITION | - |
dc.identifier.doi | 10.1002/bbd.394 | - |
dc.contributor.localauthor | Chung, WS | - |
dc.contributor.nonIdAuthor | Bae, SK | - |
dc.contributor.nonIdAuthor | Kim, EJ | - |
dc.contributor.nonIdAuthor | Rhee, JK | - |
dc.contributor.nonIdAuthor | Kwon, JW | - |
dc.contributor.nonIdAuthor | Kim, WB | - |
dc.contributor.nonIdAuthor | Lee, MG | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | DA-7867 | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordAuthor | tissue distribution | - |
dc.subject.keywordAuthor | tissue metabolism | - |
dc.subject.keywordAuthor | stability | - |
dc.subject.keywordAuthor | blood partition | - |
dc.subject.keywordAuthor | protein binding | - |
dc.subject.keywordPlus | ISOLATED RAT-LIVER | - |
dc.subject.keywordPlus | DRUG ELIMINATION | - |
dc.subject.keywordPlus | DOSAGE REGIMENS | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | ERYTHROCYTES | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | BARRIERS | - |
dc.subject.keywordPlus | AGENT | - |
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