DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Su Hwan | ko |
dc.contributor.author | Lee, Hak Rae | ko |
dc.contributor.author | Yu, Seung Jung | ko |
dc.contributor.author | Han, Min Eui | ko |
dc.contributor.author | Lee, Doh Young | ko |
dc.contributor.author | Kim, Soo Yeon | ko |
dc.contributor.author | Ahn, Hee Jin | ko |
dc.contributor.author | Han, Mi Jung | ko |
dc.contributor.author | Lee, Tae Ik | ko |
dc.contributor.author | Kim, Taek Soo | ko |
dc.contributor.author | Kwon, Seong Keun | ko |
dc.contributor.author | Im, Sung Gap | ko |
dc.contributor.author | Hwang Nathaniel S. | ko |
dc.date.accessioned | 2016-04-22T07:47:29Z | - |
dc.date.available | 2016-04-22T07:47:29Z | - |
dc.date.created | 2015-12-15 | - |
dc.date.created | 2015-12-15 | - |
dc.date.created | 2015-12-15 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.112, no.50, pp.15426 - 15431 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205710 | - |
dc.description.abstract | In this study, we present a method for assembling biofunctionalized paper into a multiform structured scaffold system for reliable tissue regeneration using an origami-based approach. The surface of a paper was conformally modified with a poly(styrene-comaleic anhydride) layer via initiated chemical vapor deposition followed by the immobilization of poly-L-lysine (PLL) and deposition of Ca2+. This procedure ensures the formation of alginate hydrogel on the paper due to Ca2+ diffusion. Furthermore, strong adhesion of the alginate hydrogel on the paper onto the paper substrate was achieved due to an electrostatic interaction between the alginate and PLL. The developed scaffold system was versatile and allowed area-selective cell seeding. Also, the hydrogel-laden paper could be folded freely into 3D tissue-like structures using a simple origami-based method. The cylindrically constructed paper scaffold system with chondrocytes was applied into a three-ring defect trachea in rabbits. The transplanted engineered tissues replaced the native trachea without stenosis after 4 wks. As for the custom-built scaffold system, the hydrogel-laden paper system will provide a robust and facile method for the formation of tissues mimicking native tissue constructs. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Hydrogel-laden paper scaffold system for origami-based tissue engineering | - |
dc.type | Article | - |
dc.identifier.wosid | 000366404200062 | - |
dc.identifier.scopusid | 2-s2.0-84950335736 | - |
dc.type.rims | ART | - |
dc.citation.volume | 112 | - |
dc.citation.issue | 50 | - |
dc.citation.beginningpage | 15426 | - |
dc.citation.endingpage | 15431 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1504745112 | - |
dc.contributor.localauthor | Kim, Taek Soo | - |
dc.contributor.localauthor | Im, Sung Gap | - |
dc.contributor.nonIdAuthor | Kim, Su Hwan | - |
dc.contributor.nonIdAuthor | Lee, Hak Rae | - |
dc.contributor.nonIdAuthor | Han, Min Eui | - |
dc.contributor.nonIdAuthor | Lee, Doh Young | - |
dc.contributor.nonIdAuthor | Kim, Soo Yeon | - |
dc.contributor.nonIdAuthor | Ahn, Hee Jin | - |
dc.contributor.nonIdAuthor | Han, Mi Jung | - |
dc.contributor.nonIdAuthor | Kwon, Seong Keun | - |
dc.contributor.nonIdAuthor | Hwang Nathaniel S. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | paper scaffolds | - |
dc.subject.keywordAuthor | origami | - |
dc.subject.keywordAuthor | tissue engineering | - |
dc.subject.keywordAuthor | initiated chemical vapor deposition | - |
dc.subject.keywordAuthor | hydrogel | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | HIGH-THROUGHPUT | - |
dc.subject.keywordPlus | CULTURE | - |
dc.subject.keywordPlus | MICROARRAY | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | ORGANS | - |
dc.subject.keywordPlus | MODEL | - |
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