This study evaluated indoor environmental characteristics in an office room equipped both with ventilation window system and central cooling system. Fresh air is supplied only by the central cooling system whereas indoor air is discharged outside through both ceiling diffuser and a ventilation window system. Numerical study is conducted by changing the volumetric flow rates of exhaust ports of each system. For estimating the performance of this coupled system, CO2 concentration and Predicted Mean Vote (PMV) were calculated using Computational Fluid Dynamics (CFD) simulation. The more the ceiling diffuser exhausts indoor air, the more the CO2 concentration decreases. However, when the ventilation window system exhausts more indoor air, thermal comfort level gets improved in the office room with cooling system. Therefore, when the ventilation window system is operated, the coupled operation with central cooling system should be considered for enhancing indoor air quality and thermal comfort, together.