DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jin Hwan | ko |
dc.contributor.author | Lee, SangYup | ko |
dc.date.accessioned | 2010-11-30T08:35:03Z | - |
dc.date.available | 2010-11-30T08:35:03Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | BIOTECHNOLOGY JOURNAL, v.5, no.6, pp.560 - 577 | - |
dc.identifier.issn | 1860-6768 | - |
dc.identifier.uri | http://hdl.handle.net/10203/20546 | - |
dc.description.abstract | The L-aspartate family amino acids (AFAAs), L-threonine, L-lysine, L-methionine and L-isoleucine have recently been of much interest due to their wide spectrum of applications including food additives, components of cosmetics and therapeutic agents, and animal feed additives. Among them, L-threonine, L-lysine and L-methionine are three major amino acids produced currently throughout the world. Recent advances in systems metabolic engineering, which combine various high-throughput omics technologies and computational analysis, are now facilitating development of microbial strains efficiently producing AFAAs. Thus, a thorough understanding of the metabolic and regulatory mechanisms of the biosynthesis of these amino acids is urgently needed for designing system-wide metabolic engineering strategies. Here we review the details of AFAA biosynthetic pathways, regulations involved, and export and transport systems, and provide general strategies for successful metabolic engineering along with relevant examples. Finally, perspectives of systems metabolic engineering for developing AFAA overproducers are suggested with selected exemplary studies. | - |
dc.description.sponsorship | This work was supported by the Korea-Australia Collaborative Research Project on the Development of Sucrose-Based Bioprocess Platform (10030795) from the Korean Ministry of Knowledge Economy. Further supports by LG Chem Chair Professorship, Microsoft, World Class University Program of the Ministry of Education, Science and Technology (MEST), and IBM-SUR program are greatly appreciated. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Metabolic pathways and fermentative production of L-aspartate family amino acids | - |
dc.type | Article | - |
dc.identifier.wosid | 000278969600004 | - |
dc.identifier.scopusid | 2-s2.0-77953140616 | - |
dc.type.rims | ART | - |
dc.citation.volume | 5 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 560 | - |
dc.citation.endingpage | 577 | - |
dc.citation.publicationname | BIOTECHNOLOGY JOURNAL | - |
dc.identifier.doi | 10.1002/biot.201000032 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, SangYup | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | L-Isoleucine | - |
dc.subject.keywordAuthor | L-Lysine | - |
dc.subject.keywordAuthor | L-Methionine | - |
dc.subject.keywordAuthor | Systems metabolic engineering | - |
dc.subject.keywordAuthor | L-Threonine | - |
dc.subject.keywordPlus | L-LYSINE PRODUCTION | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI K-12 | - |
dc.subject.keywordPlus | L-THREONINE PRODUCTION | - |
dc.subject.keywordPlus | L-ISOLEUCINE PRODUCTION | - |
dc.subject.keywordPlus | GLOBAL EXPRESSION CHANGES | - |
dc.subject.keywordPlus | GENE KNOCKOUT SIMULATION | - |
dc.subject.keywordPlus | REDUCED-GENOME STRAIN | - |
dc.subject.keywordPlus | CORYNEBACTERIUM-GLUTAMICUM | - |
dc.subject.keywordPlus | SERRATIA-MARCESCENS | - |
dc.subject.keywordPlus | SYSTEMS BIOLOGY | - |
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