DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung-Hyun | ko |
dc.contributor.author | Shin, Kihyuk | ko |
dc.contributor.author | Park, Sungha | ko |
dc.contributor.author | Kang, Seok-Min | ko |
dc.contributor.author | Choi, Donghoon | ko |
dc.contributor.author | Lee, Seung-Hyo | ko |
dc.contributor.author | Lee, Sang-Hak | ko |
dc.date.accessioned | 2016-04-20T06:14:17Z | - |
dc.date.available | 2016-04-20T06:14:17Z | - |
dc.date.created | 2015-11-30 | - |
dc.date.created | 2015-11-30 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | YONSEI MEDICAL JOURNAL, v.56, no.6, pp.1545 - 1551 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205191 | - |
dc.description.abstract | Purpose: Elastin is a major arterial structural protein, and elastin-derived peptides are related to arterial change. We previously reported on a novel assay developed using aortic elastin peptides; however, its clinical implications remain unclear. In this study, we assessed whether anti-elastin antibody titers reflect the risk of coronary artery disease (CAD) or its characteristics. Materials and Methods: We included 174 CAD patients and 171 age- and sex-matched controls. Anti-elastin antibody titers were quantified by enzyme-linked immunosorbent assay. Parameters of arterial stiffness, including the augmentation index (AI) and heart-to-femoral pulse wave velocity (hfPWV), were measured non-invasively. The clinical and angiographic characteristics of CAD patients were also evaluated. Associations between anti-elastin levels and vascular characteristics were examined by linear regression analysis. Results: The median blood level of anti-elastin was significantly lower in the CAD group than in the controls [197 arbitrary unit (a.u.) vs. 63 a.u., p<0.001]. Levels of anti-elastin were significantly lower in men and in subjects with hypertension, diabetes mellitus, hyperlipidemia, or high hfPWV. Nevertheless, anti-elastin levels were not dependent on atherothrombotic events or the angiographic severity of CAD. In a multivariate analysis, male sex beta=-0.38, p<0.001), diabetes mellitus (beta=-0.62, p<0.001), hyperlipidemia (beta=-0.29, p<0.001), and AI (beta=-0.006, p=0.02) were ultimately identified as determinants of anti-elastin levels. Conclusion: Lower levels of anti-elastin are related to CAD. The association between antibody titers and CAD is linked to arterial stiffness rather than the advancement of atherosclerosis. | - |
dc.language | English | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.subject | AGE-RELATED-CHANGES | - |
dc.subject | ELASTIN-DERIVED PEPTIDES | - |
dc.subject | PULSE-WAVE VELOCITY | - |
dc.subject | SERUM | - |
dc.subject | DEGRADATION | - |
dc.subject | CATHEPSINS | - |
dc.title | Circulating Anti-Elastin Antibody Levels and Arterial Disease Characteristics: Associations with Arterial Stiffness and Atherosclerosis | - |
dc.type | Article | - |
dc.identifier.wosid | 000363494600011 | - |
dc.identifier.scopusid | 2-s2.0-84944033687 | - |
dc.type.rims | ART | - |
dc.citation.volume | 56 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1545 | - |
dc.citation.endingpage | 1551 | - |
dc.citation.publicationname | YONSEI MEDICAL JOURNAL | - |
dc.identifier.doi | 10.3349/ymj.2015.56.6.1545 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Seung-Hyo | - |
dc.contributor.nonIdAuthor | Lee, Seung-Hyun | - |
dc.contributor.nonIdAuthor | Park, Sungha | - |
dc.contributor.nonIdAuthor | Kang, Seok-Min | - |
dc.contributor.nonIdAuthor | Choi, Donghoon | - |
dc.contributor.nonIdAuthor | Lee, Sang-Hak | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Elastin | - |
dc.subject.keywordAuthor | antibody formation | - |
dc.subject.keywordAuthor | vascular stiffness | - |
dc.subject.keywordAuthor | coronary artery disease | - |
dc.subject.keywordAuthor | atherosclerosis | - |
dc.subject.keywordPlus | AGE-RELATED-CHANGES | - |
dc.subject.keywordPlus | ELASTIN-DERIVED PEPTIDES | - |
dc.subject.keywordPlus | PULSE-WAVE VELOCITY | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | CATHEPSINS | - |
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