DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyoung-Tai | ko |
dc.contributor.author | Kim, Soung Jung | ko |
dc.contributor.author | Sohn, Young-In | ko |
dc.contributor.author | Paik, Sun-Sook | ko |
dc.contributor.author | Caplette, R | ko |
dc.contributor.author | Simonutti, Manuel | ko |
dc.contributor.author | Moon, Kyeong Hwan | ko |
dc.contributor.author | Lee, Eun Jung | ko |
dc.contributor.author | Min, Kwang Wook | ko |
dc.contributor.author | Kim, Mi Jeong | ko |
dc.contributor.author | Lee, Dong-Gi | ko |
dc.contributor.author | Simeone, Antonio | ko |
dc.contributor.author | Lamonerie, Thomas | ko |
dc.contributor.author | Furukawa, Takahisa | ko |
dc.contributor.author | Choi, Jong-Soon | ko |
dc.contributor.author | Kweon, Hee-Seok | ko |
dc.contributor.author | Picaud, Serge | ko |
dc.contributor.author | Kim, In-Beom | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Kim, Jin Woo | ko |
dc.date.accessioned | 2016-04-20T06:13:37Z | - |
dc.date.available | 2016-04-20T06:13:37Z | - |
dc.date.created | 2015-11-30 | - |
dc.date.created | 2015-11-30 | - |
dc.date.created | 2015-11-30 | - |
dc.date.created | 2015-11-30 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | CELL REPORTS, v.13, no.5, pp.990 - 1002 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205182 | - |
dc.description.abstract | OTX2 (orthodenticle homeobox 2) haplodeficiency causes diverse defects in mammalian visual systems ranging from retinal dysfunction to anophthalmia. We find that the retinal dystrophy of Otx2(+/GFP) heterozygous knockin mice is mainly due to the loss of bipolar cells and consequent deficits in retinal activity. Among bipolar cell types, OFF-cone bipolar subsets, which lack autonomous Otx2 gene expression but receive Otx2 proteins from photoreceptors, degenerate most rapidly in Otx2(+/GFP) mouse retinas, suggesting a neuroprotective effect of the imported Otx2 protein. In support of this hypothesis, retinal dystrophy in Otx2(+/GFP) mice is prevented by intraocular injection of Otx2 protein, which localizes to the mitochondria of bipolar cells and facilitates ATP synthesis as a part of mitochondrial ATP synthase complex. Taken together, our findings demonstrate a mitochondrial function for Otx2 and suggest a potential therapeutic application of OTX2 protein delivery in human retinal dystrophy. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons | - |
dc.type | Article | - |
dc.identifier.wosid | 000363988100014 | - |
dc.identifier.scopusid | 2-s2.0-84947440935 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 990 | - |
dc.citation.endingpage | 1002 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2015.09.075 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.localauthor | Kim, Jin Woo | - |
dc.contributor.nonIdAuthor | Kim, Hyoung-Tai | - |
dc.contributor.nonIdAuthor | Kim, Soung Jung | - |
dc.contributor.nonIdAuthor | Sohn, Young-In | - |
dc.contributor.nonIdAuthor | Paik, Sun-Sook | - |
dc.contributor.nonIdAuthor | Caplette, R | - |
dc.contributor.nonIdAuthor | Simonutti, Manuel | - |
dc.contributor.nonIdAuthor | Moon, Kyeong Hwan | - |
dc.contributor.nonIdAuthor | Lee, Eun Jung | - |
dc.contributor.nonIdAuthor | Min, Kwang Wook | - |
dc.contributor.nonIdAuthor | Kim, Mi Jeong | - |
dc.contributor.nonIdAuthor | Lee, Dong-Gi | - |
dc.contributor.nonIdAuthor | Simeone, Antonio | - |
dc.contributor.nonIdAuthor | Lamonerie, Thomas | - |
dc.contributor.nonIdAuthor | Furukawa, Takahisa | - |
dc.contributor.nonIdAuthor | Choi, Jong-Soon | - |
dc.contributor.nonIdAuthor | Kweon, Hee-Seok | - |
dc.contributor.nonIdAuthor | Picaud, Serge | - |
dc.contributor.nonIdAuthor | Kim, In-Beom | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PHOTORECEPTOR CELL FATE | - |
dc.subject.keywordPlus | VISUAL-CORTEX | - |
dc.subject.keywordPlus | BIPOLAR CELLS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | SPECIFICATION | - |
dc.subject.keywordPlus | HOMEOPROTEIN | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | PHENOTYPES | - |
dc.subject.keywordPlus | MUTATIONS | - |
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