DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sharker, Shazid Md. | ko |
dc.contributor.author | Kim, Sung Min | ko |
dc.contributor.author | Lee, Jung Eun | ko |
dc.contributor.author | Choi, Kyung Ho | ko |
dc.contributor.author | Shin, Gyojic | ko |
dc.contributor.author | Lee, Sangkug | ko |
dc.contributor.author | Lee, Kang Dae | ko |
dc.contributor.author | Jeong, Ji Hoon | ko |
dc.contributor.author | Lee, Haeshin | ko |
dc.contributor.author | Park, Sung Young | ko |
dc.date.accessioned | 2016-04-20T06:13:27Z | - |
dc.date.available | 2016-04-20T06:13:27Z | - |
dc.date.created | 2015-11-30 | - |
dc.date.created | 2015-11-30 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v.217, pp.211 - 220 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205180 | - |
dc.description.abstract | We report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO3) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO3-HA) to a tumor site. Near-infrared (NIR) irradiated WO3-HA showed a rapid and substantial rise in photothermal heat to complete in vitro thermolysis of malignant MDAMB and A549 cancer cellsbut was found to be relatively less sensitive to normal MDCK cells. A long-term in vivo investigation of similar to 10 nm HA thickness on WO3 (WO3-HA) nanoparticles demonstrated efficient photo-thermal conversion with time-dependent tumor target accumulation. This long-term in vivo survival study of WO3-HA showed promising biocompatibility, with a complete recovery from malignant tumor. Due to the importance of keeping simplicity in the design of therapeutic nanoparticles, we therefore expect that this facile scheme (HA-D) would contribute to the biocompatible development of versatile metallic nanoparticles for photothermal applications. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | HYALURONIC-ACID NANOPARTICLES | - |
dc.subject | REDUCED GRAPHENE OXIDE | - |
dc.subject | 980 NM-LASER | - |
dc.subject | CARBON NANOPARTICLES | - |
dc.subject | GOLD NANOPARTICLES | - |
dc.subject | POLYMER | - |
dc.subject | LIGHT | - |
dc.subject | CHEMISTRY | - |
dc.subject | ABLATION | - |
dc.subject | DELIVERY | - |
dc.title | Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000363481500021 | - |
dc.identifier.scopusid | 2-s2.0-84941955974 | - |
dc.type.rims | ART | - |
dc.citation.volume | 217 | - |
dc.citation.beginningpage | 211 | - |
dc.citation.endingpage | 220 | - |
dc.citation.publicationname | JOURNAL OF CONTROLLED RELEASE | - |
dc.identifier.doi | 10.1016/j.jconrel.2015.09.010 | - |
dc.contributor.localauthor | Lee, Haeshin | - |
dc.contributor.nonIdAuthor | Kim, Sung Min | - |
dc.contributor.nonIdAuthor | Lee, Jung Eun | - |
dc.contributor.nonIdAuthor | Choi, Kyung Ho | - |
dc.contributor.nonIdAuthor | Shin, Gyojic | - |
dc.contributor.nonIdAuthor | Lee, Sangkug | - |
dc.contributor.nonIdAuthor | Lee, Kang Dae | - |
dc.contributor.nonIdAuthor | Jeong, Ji Hoon | - |
dc.contributor.nonIdAuthor | Park, Sung Young | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | WO3 | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Biocompatibility | - |
dc.subject.keywordAuthor | Target delivery | - |
dc.subject.keywordAuthor | Photothermal therapy | - |
dc.subject.keywordPlus | HYALURONIC-ACID NANOPARTICLES | - |
dc.subject.keywordPlus | REDUCED GRAPHENE OXIDE | - |
dc.subject.keywordPlus | 980 NM-LASER | - |
dc.subject.keywordPlus | CARBON NANOPARTICLES | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | ABLATION | - |
dc.subject.keywordPlus | DELIVERY | - |
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