DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cahoon, Judd M. | ko |
dc.contributor.author | Rai, Ruju R. | ko |
dc.contributor.author | Carroll, Lara S. | ko |
dc.contributor.author | Uehara, Hironori | ko |
dc.contributor.author | Zhang, Xiaohui | ko |
dc.contributor.author | O'Neil, Christina L. | ko |
dc.contributor.author | Medina, Reinhold J. | ko |
dc.contributor.author | Das, Subtrata K. | ko |
dc.contributor.author | Muddana, Santosh K. | ko |
dc.contributor.author | Olson, Paul R. | ko |
dc.contributor.author | Nielson, Spencer | ko |
dc.contributor.author | Walker, Kortnie | ko |
dc.contributor.author | Flood, Maggie M. | ko |
dc.contributor.author | Messenger, Wyatt B. | ko |
dc.contributor.author | Archer, Bonnie J. | ko |
dc.contributor.author | Barabas, Peter | ko |
dc.contributor.author | Krizaj, David | ko |
dc.contributor.author | Gibson, Christopher C. | ko |
dc.contributor.author | Li, Dean Y. | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Gao, Guangping | ko |
dc.contributor.author | Stitt, Alan W. | ko |
dc.contributor.author | Ambati, Balamurali K. | ko |
dc.date.accessioned | 2016-04-20T06:08:33Z | - |
dc.date.available | 2016-04-20T06:08:33Z | - |
dc.date.created | 2015-12-30 | - |
dc.date.created | 2015-12-30 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | DIABETES, v.64, no.12, pp.4247 - 4259 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205111 | - |
dc.description.abstract | Diabetic retinopathy (DR) is the leading cause of blindness in the working-age population in the U.S. The vision-threatening processes of neuroglial and vascular dysfunction in DR occur in concert, driven by hyperglycemia and propelled by a pathway of inflammation, ischemia, vasodegeneration, and breakdown of the blood retinal barrier. Currently, no therapies exist for normalizing the vasculature in DR. Here, we show that a single intravitreal dose of adeno-associated virus serotype 2 encoding a more stable, soluble, and potent form of angiopoietin 1 (AAV2.COMP-Ang1) can ameliorate the structural and functional hallmarks of DR in Ins2Akita mice, with sustained effects observed through six months. In early DR, AAV2.COMP-Ang1 restored leukocyte-endothelial interaction, retinal oxygenation, vascular density, vascular marker expression, vessel permeability, retinal thickness, inner retinal cellularity, and retinal neurophysiological response to levels comparable with nondiabetic controls. In late DR, AAV2.COMP-Ang1 enhanced the therapeutic benefit of intravitreally delivered endothelial colony-forming cells by promoting their integration into the vasculature and thereby stemming further visual decline. AAV2.COMP-Ang1 single-dose gene therapy can prevent neurovascular pathology, support vascular regeneration, and stabilize vision in DR. | - |
dc.language | English | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | MACULAR EDEMA | - |
dc.subject | GLOBAL PREVALENCE | - |
dc.subject | INS2(AKITA) MOUSE | - |
dc.subject | ANGIOPOIETIN-1 | - |
dc.subject | CELLS | - |
dc.subject | INJURY | - |
dc.subject | VEGF | - |
dc.subject | COMP-ANG1 | - |
dc.subject | LEAKAGE | - |
dc.title | Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy | - |
dc.type | Article | - |
dc.identifier.wosid | 000365932900029 | - |
dc.identifier.scopusid | 2-s2.0-84962191237 | - |
dc.type.rims | ART | - |
dc.citation.volume | 64 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 4247 | - |
dc.citation.endingpage | 4259 | - |
dc.citation.publicationname | DIABETES | - |
dc.identifier.doi | 10.2337/db14-1030 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Cahoon, Judd M. | - |
dc.contributor.nonIdAuthor | Rai, Ruju R. | - |
dc.contributor.nonIdAuthor | Carroll, Lara S. | - |
dc.contributor.nonIdAuthor | Uehara, Hironori | - |
dc.contributor.nonIdAuthor | Zhang, Xiaohui | - |
dc.contributor.nonIdAuthor | O'Neil, Christina L. | - |
dc.contributor.nonIdAuthor | Medina, Reinhold J. | - |
dc.contributor.nonIdAuthor | Das, Subtrata K. | - |
dc.contributor.nonIdAuthor | Muddana, Santosh K. | - |
dc.contributor.nonIdAuthor | Olson, Paul R. | - |
dc.contributor.nonIdAuthor | Nielson, Spencer | - |
dc.contributor.nonIdAuthor | Walker, Kortnie | - |
dc.contributor.nonIdAuthor | Flood, Maggie M. | - |
dc.contributor.nonIdAuthor | Messenger, Wyatt B. | - |
dc.contributor.nonIdAuthor | Archer, Bonnie J. | - |
dc.contributor.nonIdAuthor | Barabas, Peter | - |
dc.contributor.nonIdAuthor | Krizaj, David | - |
dc.contributor.nonIdAuthor | Gibson, Christopher C. | - |
dc.contributor.nonIdAuthor | Li, Dean Y. | - |
dc.contributor.nonIdAuthor | Gao, Guangping | - |
dc.contributor.nonIdAuthor | Stitt, Alan W. | - |
dc.contributor.nonIdAuthor | Ambati, Balamurali K. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | MACULAR EDEMA | - |
dc.subject.keywordPlus | GLOBAL PREVALENCE | - |
dc.subject.keywordPlus | INS2(AKITA) MOUSE | - |
dc.subject.keywordPlus | ANGIOPOIETIN-1 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | COMP-ANG1 | - |
dc.subject.keywordPlus | LEAKAGE | - |
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