DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, Yoon Seok | ko |
dc.contributor.author | Bhat, Shreelatha | ko |
dc.contributor.author | Hong, Seung-Hyun | ko |
dc.contributor.author | Shin, Minjung | ko |
dc.contributor.author | Bahk, Suhyoung | ko |
dc.contributor.author | Cho, Kyung Sang | ko |
dc.contributor.author | Kim, Seung-Whan | ko |
dc.contributor.author | Lee, Kyu-Sun | ko |
dc.contributor.author | Kim, Young-Joon | ko |
dc.contributor.author | Jones, Walton D | ko |
dc.contributor.author | Yu, Kweon | ko |
dc.date.accessioned | 2016-04-15T03:09:49Z | - |
dc.date.available | 2016-04-15T03:09:49Z | - |
dc.date.created | 2015-09-01 | - |
dc.date.created | 2015-09-01 | - |
dc.date.created | 2015-09-01 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.6 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/204011 | - |
dc.description.abstract | MicroRNAs (miRNAs) regulate many physiological processes including body growth. Insulin/ IGF signalling is the primary regulator of animal body growth, but the extent to which miRNAs act in insulin-producing cells (IPCs) is unclear. Here we generate a UAS-miRNA library of Drosophila stocks and perform a genetic screen to identify miRNAs whose overexpression in the IPCs inhibits body growth in Drosophila. Through this screen, we identify miR-9a as an evolutionarily conserved regulator of insulin signalling and body growth. IPC-specific miR-9a overexpression reduces insulin signalling and body size. Of the predicted targets of miR-9a, we find that loss of miR-9a enhances the level of sNPFR1. We show via an in vitro binding assay that miR-9a binds to sNPFR1 mRNA in insect cells and to the mammalian orthologue NPY2R in rat insulinoma cells. These findings indicate that the conserved miR-9a regulates body growth by controlling sNPFR1/NPYR-mediated modulation of insulin signalling. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Genome-wide microRNA screening reveals that the evolutionary conserved miR-9a regulates body growth by targeting sNPFR1/NPYR | - |
dc.type | Article | - |
dc.identifier.wosid | 000358858100037 | - |
dc.identifier.scopusid | 2-s2.0-84936775014 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms8693 | - |
dc.contributor.localauthor | Jones, Walton D | - |
dc.contributor.nonIdAuthor | Suh, Yoon Seok | - |
dc.contributor.nonIdAuthor | Hong, Seung-Hyun | - |
dc.contributor.nonIdAuthor | Shin, Minjung | - |
dc.contributor.nonIdAuthor | Cho, Kyung Sang | - |
dc.contributor.nonIdAuthor | Kim, Seung-Whan | - |
dc.contributor.nonIdAuthor | Lee, Kyu-Sun | - |
dc.contributor.nonIdAuthor | Kim, Young-Joon | - |
dc.contributor.nonIdAuthor | Yu, Kweon | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INSULIN-LIKE PEPTIDES | - |
dc.subject.keywordPlus | NEUROPEPTIDE-Y | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | CELLS | - |
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