DC Field | Value | Language |
---|---|---|
dc.contributor.author | You, Chan Ran | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Jeong, Sung Won | ko |
dc.contributor.author | Woo, Hyun Young | ko |
dc.contributor.author | Bae, Si Hyun | ko |
dc.contributor.author | Choi, Jong Young | ko |
dc.contributor.author | Sung, Young Chul | ko |
dc.contributor.author | Yoon, Seung Kew | ko |
dc.date.accessioned | 2015-11-20T10:24:20Z | - |
dc.date.available | 2015-11-20T10:24:20Z | - |
dc.date.created | 2014-10-02 | - |
dc.date.created | 2014-10-02 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.citation | GUT AND LIVER, v.5, no.4, pp.506 - 512 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | http://hdl.handle.net/10203/201391 | - |
dc.description.abstract | Background/Aims: Interferon-gamma-inducible protein 10 (IP-10) plays important roles in the pathogenesis of hepatitis C virus (HCV) infection. We investigated the association between serum IP-10 levels and liver pathology in patients with chronic HCV infection. Methods: The serum IP-10 concentration was assessed in 85 patients with chronic HCV infection using a solid phase sandwich enzyme-linked immunosorbent assay, and a liver biopsy specimen was obtained. The pathology was scored using the Knodell histologic activity index (HAI). Results: Of the 85 patients, 58 had genotype 1 HCV infection, 21 had genotype non-1, and 6 were undetermined. The serum IP-10 levels did not differ between patients infected with genotype 1 and genotype non-1 (p=0.472). In patients with genotype 1 infection, the total HAI score and the stage of fibrosis were highly correlated with the serum IP-10 level (r=0.555, r=0.578, p<0.001). Furthermore, the serum IP-10 concentrations of patients with severe fibrosis (stages 3, 4) were higher than those of patients with mild fibrosis (stages 0 to 2; 214.4 vs. 72.3 pg/mL, p=0.002) among patients with genotype 1 infection. However, in patients without genotype 1 infection, the histopathology was not associated with the serum IP-10 level. A multivariate analysis showed that serum IP-10 was an independent predictor of fibrosis (stages 3, 4) in patients with genotype 1 infection (odds ratio, 1.034; 95% confidence interval, 1.006 to 1.064; p=0.018). Conclusions: Serum IP-10 concentration was significantly correlated with the severity of liver histology in genotype 1 HCV infection. (Gut Liver 2011;5:506-512) | - |
dc.language | English | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.subject | CHRONIC HEPATITIS-C | - |
dc.subject | VIRUS-INFECTION | - |
dc.subject | INDUCIBLE PROTEIN-10 | - |
dc.subject | CHEMOKINE RECEPTORS | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | IFN-GAMMA | - |
dc.subject | T-CELLS | - |
dc.subject | EXPRESSION | - |
dc.subject | LYMPHOCYTES | - |
dc.subject | ACCUMULATION | - |
dc.title | Serum IP-10 Levels Correlate with the Severity of Liver Histopathology in Patients Infected with Genotype-1 HCV | - |
dc.type | Article | - |
dc.identifier.wosid | 000297428100016 | - |
dc.identifier.scopusid | 2-s2.0-81855184381 | - |
dc.type.rims | ART | - |
dc.citation.volume | 5 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 506 | - |
dc.citation.endingpage | 512 | - |
dc.citation.publicationname | GUT AND LIVER | - |
dc.identifier.doi | 10.5009/gnl.2011.5.4.506 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.nonIdAuthor | You, Chan Ran | - |
dc.contributor.nonIdAuthor | Jeong, Sung Won | - |
dc.contributor.nonIdAuthor | Woo, Hyun Young | - |
dc.contributor.nonIdAuthor | Bae, Si Hyun | - |
dc.contributor.nonIdAuthor | Choi, Jong Young | - |
dc.contributor.nonIdAuthor | Sung, Young Chul | - |
dc.contributor.nonIdAuthor | Yoon, Seung Kew | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Chronic hepatitis C | - |
dc.subject.keywordAuthor | Fibrosis | - |
dc.subject.keywordAuthor | Interferon-gamma-inducible protein 10 | - |
dc.subject.keywordPlus | CHRONIC HEPATITIS-C | - |
dc.subject.keywordPlus | VIRUS-INFECTION | - |
dc.subject.keywordPlus | INDUCIBLE PROTEIN-10 | - |
dc.subject.keywordPlus | CHEMOKINE RECEPTORS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | ACCUMULATION | - |
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