DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Sunkyu | ko |
dc.contributor.author | Le, Binh V. | ko |
dc.contributor.author | Hajare, Holly S. | ko |
dc.contributor.author | Baxter, Richard H. G. | ko |
dc.contributor.author | Miller, Scott J. | ko |
dc.date.accessioned | 2015-11-20T09:12:20Z | - |
dc.date.available | 2015-11-20T09:12:20Z | - |
dc.date.created | 2014-11-20 | - |
dc.date.created | 2014-11-20 | - |
dc.date.created | 2014-11-20 | - |
dc.date.created | 2014-11-20 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.citation | JOURNAL OF ORGANIC CHEMISTRY, v.79, no.18, pp.8550 - 8556 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | http://hdl.handle.net/10203/201084 | - |
dc.description.abstract | We report the X-ray crystal structure of a site-selective peptide catalyst moiety and teicoplanin A2-2 complex. The expressed protein ligation technique was used to couple T4 lysozyme (T4L) and a synthetic peptide catalyst responsible for the selective phosphorylation of the N-acetylglucosamine sugar in a teicoplanin A2-2 derivative. The T4L-Pmh-dPro-Aib-dAla-dAla construct was crystallized in the presence of teicoplanin A2-2. The resulting 2.3 Å resolution protein–peptide–teicoplanin complex crystal structure revealed that the nucleophilic nitrogen of N-methylimidazole in the Pmh residue is in closer proximity (7.6 Å) to the N-acetylglucosamine than the two other sugar rings present in teicoplanin (9.3 and 20.3 Å, respectively). This molecular arrangement is consistent with the observed selectivity afforded by the peptide-based catalyst when it is applied to a site-selective phosphorylation reaction involving a teicoplanin A2-2 derivative. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | X-ray Crystal Structure of Teicoplanin A2-2 Bound to a Catalytic Peptide Sequence via the Carrier Protein Strategy | - |
dc.type | Article | - |
dc.identifier.wosid | 000342121100006 | - |
dc.identifier.scopusid | 2-s2.0-84911899902 | - |
dc.type.rims | ART | - |
dc.citation.volume | 79 | - |
dc.citation.issue | 18 | - |
dc.citation.beginningpage | 8550 | - |
dc.citation.endingpage | 8556 | - |
dc.citation.publicationname | JOURNAL OF ORGANIC CHEMISTRY | - |
dc.identifier.doi | 10.1021/jo501625f | - |
dc.contributor.localauthor | Han, Sunkyu | - |
dc.contributor.nonIdAuthor | Le, Binh V. | - |
dc.contributor.nonIdAuthor | Hajare, Holly S. | - |
dc.contributor.nonIdAuthor | Baxter, Richard H. G. | - |
dc.contributor.nonIdAuthor | Miller, Scott J. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ASYMMETRIC PHOSPHORYLATION | - |
dc.subject.keywordPlus | CARDIAC GLYCOSIDE | - |
dc.subject.keywordPlus | HAIRPIN FORMATION | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | VANCOMYCIN | - |
dc.subject.keywordPlus | LIGATION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | DEOXYGENATION | - |
dc.subject.keywordPlus | SEMISYNTHESIS | - |
dc.subject.keywordPlus | GLYCOPEPTIDE | - |
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