DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jin-A | ko |
dc.contributor.author | Lee, Sue-Hyun | ko |
dc.contributor.author | Lee, Changhoon | ko |
dc.contributor.author | Chang, Deok-Jin | ko |
dc.contributor.author | Lee, Yong | ko |
dc.contributor.author | Kim, Hyoung | ko |
dc.contributor.author | Cheang, Ye-Hwang | ko |
dc.contributor.author | Ko, Hyoung-Gon | ko |
dc.contributor.author | Lee, Yong-Seok | ko |
dc.contributor.author | Jun, Heejung | ko |
dc.contributor.author | Dusan Bartsch | ko |
dc.contributor.author | Kandel, Eric R | ko |
dc.contributor.author | Kaang, Bong-Kiun | ko |
dc.date.accessioned | 2015-06-29T04:51:56Z | - |
dc.date.available | 2015-06-29T04:51:56Z | - |
dc.date.created | 2015-06-26 | - |
dc.date.created | 2015-06-26 | - |
dc.date.created | 2015-06-26 | - |
dc.date.issued | 2006-09 | - |
dc.identifier.citation | JOURNAL OF CELL BIOLOGY, v.174, no.6, pp.827 - 838 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.uri | http://hdl.handle.net/10203/199526 | - |
dc.description.abstract | Long-term memory requires transcriptional regulation by a combination of positive and negative transcription factors. Aplysia activating factor ( ApAF) is known to be a positive transcription factor that forms heterodimers with ApC/EBP and ApCREB2. How these heterodimers are regulated and how they participate in the consolidation of long-term facilitation (LTF) has not, however, been characterized. We found that the functional activation of ApAF required phosphorylation of ApAF by PKA on Ser-266. In addition, ApAF lowered the threshold of LTF by forming a heterodimer with ApCREB2. Moreover, once activated by PKA, the ApAF-ApC/EBP heterodimer transactivates enhancer response element containing genes and can induce LTF in the absence of CRE- and CREB-mediated gene expression. Collectively, these results suggest that PKA-activated ApAF-ApC/EBP heterodimer is a core downstream effector of ApCREB in the consolidation of LTF. | - |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.title | PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation | - |
dc.type | Article | - |
dc.identifier.wosid | 000240697100012 | - |
dc.type.rims | ART | - |
dc.citation.volume | 174 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 827 | - |
dc.citation.endingpage | 838 | - |
dc.citation.publicationname | JOURNAL OF CELL BIOLOGY | - |
dc.identifier.doi | 10.1083/jcb.200512066 | - |
dc.contributor.localauthor | Lee, Sue-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Jin-A | - |
dc.contributor.nonIdAuthor | Lee, Changhoon | - |
dc.contributor.nonIdAuthor | Chang, Deok-Jin | - |
dc.contributor.nonIdAuthor | Lee, Yong | - |
dc.contributor.nonIdAuthor | Kim, Hyoung | - |
dc.contributor.nonIdAuthor | Cheang, Ye-Hwang | - |
dc.contributor.nonIdAuthor | Ko, Hyoung-Gon | - |
dc.contributor.nonIdAuthor | Lee, Yong-Seok | - |
dc.contributor.nonIdAuthor | Jun, Heejung | - |
dc.contributor.nonIdAuthor | Dusan Bartsch | - |
dc.contributor.nonIdAuthor | Kandel, Eric R | - |
dc.contributor.nonIdAuthor | Kaang, Bong-Kiun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | APLYSIA SENSORY NEURONS | - |
dc.subject.keywordPlus | ENHANCER-BINDING PROTEIN | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MEMORY STORAGE | - |
dc.subject.keywordPlus | CYCLIC-AMP | - |
dc.subject.keywordPlus | BEHAVIORAL SENSITIZATION | - |
dc.subject.keywordPlus | SYNAPTIC FACILITATION | - |
dc.subject.keywordPlus | RNA INTERFERENCE | - |
dc.subject.keywordPlus | RESPONSE ELEMENT | - |
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