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College of Engineering(공과대학)Dept. of Materials Science and Engineering(신소재공학과)MS-Journal Papers(저널논문)

Dendrimeric siRNA for Efficient Gene Silencing

Cited 57 time in webofscience Cited 49 time in scopus
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dc.contributor.authorHong, Cheol-Amko
dc.contributor.authorEltoukhy, Ahmed A.ko
dc.contributor.authorLee, Hyukjinko
dc.contributor.authorLanger, Robertko
dc.contributor.authorAnderson, Daniel G.ko
dc.contributor.authorNam, Yoon-Sungko
dc.date.accessioned2015-06-29T04:44:41Z-
dc.date.available2015-06-29T04:44:41Z-
dc.date.created2015-06-23-
dc.date.created2015-06-23-
dc.date.created2015-06-23-
dc.date.issued2015-06-
dc.identifier.citationANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.54, no.23, pp.6740 - 6744-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10203/199459-
dc.description.abstractProgrammable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(-amino ester), PBAE) to generate stable nanostructures about 160nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleDendrimeric siRNA for Efficient Gene Silencing-
dc.typeArticle-
dc.identifier.wosid000355314100007-
dc.identifier.scopusid2-s2.0-84930198696-
dc.type.rimsART-
dc.citation.volume54-
dc.citation.issue23-
dc.citation.beginningpage6740-
dc.citation.endingpage6744-
dc.citation.publicationnameANGEWANDTE CHEMIE-INTERNATIONAL EDITION-
dc.identifier.doi10.1002/anie.201412493-
dc.contributor.localauthorNam, Yoon-Sung-
dc.contributor.nonIdAuthorEltoukhy, Ahmed A.-
dc.contributor.nonIdAuthorLee, Hyukjin-
dc.contributor.nonIdAuthorLanger, Robert-
dc.contributor.nonIdAuthorAnderson, Daniel G.-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthordendrimeric nanostructures-
dc.subject.keywordAuthorgene silencing-
dc.subject.keywordAuthorpoly(-amino ester)-
dc.subject.keywordAuthorpolymeric condensation-
dc.subject.keywordAuthorsiRNA-
dc.subject.keywordPlusSMALL-INTERFERING RNA-
dc.subject.keywordPlusPOLY(BETA-AMINO ESTERS)-
dc.subject.keywordPlusINTRACELLULAR DELIVERY-
dc.subject.keywordPlusCATIONIC POLYMERS-
dc.subject.keywordPlusMAMMALIAN-CELLS-
dc.subject.keywordPlusPLASMID DNA-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusLIBRARY-
dc.subject.keywordPlusACID-
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MS-Journal Papers(저널논문)
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