DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, TY | ko |
dc.contributor.author | Kim, Hyun Uk | ko |
dc.contributor.author | Song, H | ko |
dc.contributor.author | Lee, SangYup | ko |
dc.date.accessioned | 2010-11-15T01:24:17Z | - |
dc.date.available | 2010-11-15T01:24:17Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-11 | - |
dc.identifier.citation | JOURNAL OF BIOTECHNOLOGY, v.144, no.3, pp.184 - 189 | - |
dc.identifier.issn | 0168-1656 | - |
dc.identifier.uri | http://hdl.handle.net/10203/19878 | - |
dc.description.abstract | This study presents an in-depth study on the physiological behavior of Mannheimia succiniciproducens, a capnophilic bacterium and an efficient succinic acid producer, under varying gas conditions as H-2 and CO2 play important roles in the production of succinic acid. Constraints-based flux analysis of the genome-scale metabolic model of M. succiniciproducens was performed to estimate the production patterns of several organic acids in response to varying H-2. CO2, and glucose uptake rates. Results from controlled cultivations performed previously and constraints-based flux analyses of M. succiniciproducens in this study revealed that there is an optimal range of CO2 level in the medium for enhancing cell growth and succinic acid production at a given glucose uptake rate. Furthermore, the uptake rates of H-2 and CO2 from the medium have a direct relationship with each other, significantly influencing the rates of cell growth and succinic acid production. Predictions made in this study quantitatively describe the physiological changes of the cell in response to varying H-2, CO2, and glucose uptake rates, which consequently allow us to identify the feasible physiological states of the cell with respect to cell growth rate and succinic acid production rate. (C) 2009 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | This work was supported by the Genome-based Integrated Bioprocess Development Project of the Ministry of Education, Science and Technology (No. 2005-01294) through the Korea Science and Engineering Foundation (KOSEF). Further supports by the World Class University Program from the MEST, LG Chem Chair Professorship, IBM SUR program, and Microsoft are appreciated. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | In silico analysis of the effects of H-2 and CO2 on the metabolism of a capnophilic bacterium Mannheimia succiniciproducens | - |
dc.type | Article | - |
dc.identifier.wosid | 000272861600004 | - |
dc.identifier.scopusid | 2-s2.0-70449713750 | - |
dc.type.rims | ART | - |
dc.citation.volume | 144 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 184 | - |
dc.citation.endingpage | 189 | - |
dc.citation.publicationname | JOURNAL OF BIOTECHNOLOGY | - |
dc.identifier.doi | 10.1016/j.jbiotec.2009.06.003 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Hyun Uk | - |
dc.contributor.localauthor | Lee, SangYup | - |
dc.contributor.nonIdAuthor | Kim, TY | - |
dc.contributor.nonIdAuthor | Song, H | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Mannheimia succiniciproducens | - |
dc.subject.keywordAuthor | H-2 | - |
dc.subject.keywordAuthor | CO2 | - |
dc.subject.keywordAuthor | Constraints-based flux analysis | - |
dc.subject.keywordAuthor | Succinic acid | - |
dc.subject.keywordPlus | SUCCINIC ACID PRODUCTION | - |
dc.subject.keywordPlus | GENE KNOCKOUT SIMULATION | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | SYSTEMS BIOLOGY | - |
dc.subject.keywordPlus | GENOME SEQUENCE | - |
dc.subject.keywordPlus | FLUX ANALYSIS | - |
dc.subject.keywordPlus | RUMEN | - |
dc.subject.keywordPlus | MICROORGANISMS | - |
dc.subject.keywordPlus | BIOPROCESS | - |
dc.subject.keywordPlus | GROWTH | - |
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