DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, JW | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Cho, JH | ko |
dc.contributor.author | Sung, YC | ko |
dc.date.accessioned | 2015-04-29T01:30:32Z | - |
dc.date.available | 2015-04-29T01:30:32Z | - |
dc.date.created | 2014-10-02 | - |
dc.date.created | 2014-10-02 | - |
dc.date.issued | 2003-11 | - |
dc.identifier.citation | JOURNAL OF VIROLOGY, v.77, no.21, pp.11596 - 11602 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10203/198329 | - |
dc.description.abstract | Although DNA immunization is a safe and efficient method for inducing cellular immune responses, it generates relatively weak and slow immune responses. Here, we investigated the effect of hepatitis C virus (HCV) antigen modifications on the induction of T-cell responses in DNA immunization. It is likely that the strength of T-cell responses has an inverse relationship with the length of the insert DNA. Interestingly, a mixture of several plasmids carrying each gene induced a higher level of T-cell responses than a single plasmid expressing a long polyprotein. Moreover, the presence of a transmembrane domain in HCV E2 resulted in stronger T-cell responses against E2 protein than its absence. Taken together, our results indicate that the tailored modifications of DNA-encoded antigens are capable of optimizing the induction of T-cell responses which is required for eliminating the cells chronically infected with highly variable viruses such as HCV and human immunodeficiency virus. | - |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.subject | HUMORAL IMMUNE-RESPONSES | - |
dc.subject | PLASMID DNA | - |
dc.subject | ANTIBODY-RESPONSES | - |
dc.subject | ENVELOPE PROTEINS | - |
dc.subject | CODON USAGE | - |
dc.subject | VACCINE | - |
dc.subject | GENE | - |
dc.subject | EXPRESSION | - |
dc.subject | EFFICACY | - |
dc.subject | EPITOPES | - |
dc.title | Optimal induction of T-cell responses against hepatitis C virus E2 by antigen engineering in DNA immunization | - |
dc.type | Article | - |
dc.identifier.wosid | 000185995300030 | - |
dc.identifier.scopusid | 2-s2.0-0142028863 | - |
dc.type.rims | ART | - |
dc.citation.volume | 77 | - |
dc.citation.issue | 21 | - |
dc.citation.beginningpage | 11596 | - |
dc.citation.endingpage | 11602 | - |
dc.citation.publicationname | JOURNAL OF VIROLOGY | - |
dc.identifier.doi | 10.1128/JVI.77.21.11596-11602.2003 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.nonIdAuthor | Youn, JW | - |
dc.contributor.nonIdAuthor | Cho, JH | - |
dc.contributor.nonIdAuthor | Sung, YC | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HUMORAL IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | PLASMID DNA | - |
dc.subject.keywordPlus | ANTIBODY-RESPONSES | - |
dc.subject.keywordPlus | ENVELOPE PROTEINS | - |
dc.subject.keywordPlus | CODON USAGE | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | EPITOPES | - |
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