DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Yongje | ko |
dc.contributor.author | Yoo, Changho | ko |
dc.contributor.author | Moon, Youngtaek | ko |
dc.contributor.author | Lee, Yunho | ko |
dc.contributor.author | Hong, Sung-Woo | ko |
dc.date.accessioned | 2015-04-29T01:22:32Z | - |
dc.date.available | 2015-04-29T01:22:32Z | - |
dc.date.created | 2015-04-09 | - |
dc.date.created | 2015-04-09 | - |
dc.date.created | 2015-04-09 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.citation | CHEMISTRY-AN ASIAN JOURNAL, v.10, no.4, pp.878 - 881 | - |
dc.identifier.issn | 1861-4728 | - |
dc.identifier.uri | http://hdl.handle.net/10203/198284 | - |
dc.description.abstract | FrutinoneA, a biologically active ingredient of an antimicrobial herbal extract, demonstrates potent inhibitory activity towards the CYP1A2 enzyme. A three-step total synthesis of frutinoneA with an overall yield of 44% is presented. The construction of the chromone-annelated coumarin core was achieved through palladium-catalyzed CH carbonylation of 2-phenolchromones. The straightforward synthetic route allowed facile substitutions around the frutinoneA core and thus rapid exploration of the structure-activity relationship (SAR) profile of the derivatives. The inhibitory activity of the synthesized frutinoneA derivatives were determined for CYP1A2, and ten compounds exhibited one-to-two digit nanomolar inhibitory activity towards the CYP1A2 enzyme. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | BOND ACTIVATION | - |
dc.subject | OXIDATIVE CARBONYLATION | - |
dc.subject | CHROMONES | - |
dc.subject | FLAVONES | - |
dc.subject | FUNCTIONALIZATION | - |
dc.subject | CYCLIZATION | - |
dc.subject | COUMARINS | - |
dc.subject | 2-ARYLPHENOLS | - |
dc.subject | FRUTICOSA | - |
dc.subject | ALCOHOLS | - |
dc.title | Efficient Synthesis of Frutinone A and Its Derivatives through Palladium-Catalyzed C-H Activation/Carbonylation | - |
dc.type | Article | - |
dc.identifier.wosid | 000351623600013 | - |
dc.identifier.scopusid | 2-s2.0-84925638407 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 878 | - |
dc.citation.endingpage | 881 | - |
dc.citation.publicationname | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.identifier.doi | 10.1002/asia.201402876 | - |
dc.contributor.localauthor | Lee, Yunho | - |
dc.contributor.localauthor | Hong, Sung-Woo | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | carbonylation | - |
dc.subject.keywordAuthor | CH functionalization | - |
dc.subject.keywordAuthor | frutinoneA | - |
dc.subject.keywordAuthor | palladium | - |
dc.subject.keywordAuthor | structure-activity relationships | - |
dc.subject.keywordAuthor | carbonylation | - |
dc.subject.keywordAuthor | CH functionalization | - |
dc.subject.keywordAuthor | frutinoneA | - |
dc.subject.keywordAuthor | palladium | - |
dc.subject.keywordAuthor | structure-activity relationships | - |
dc.subject.keywordPlus | BOND ACTIVATION | - |
dc.subject.keywordPlus | OXIDATIVE CARBONYLATION | - |
dc.subject.keywordPlus | CHROMONES | - |
dc.subject.keywordPlus | FLAVONES | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordPlus | CYCLIZATION | - |
dc.subject.keywordPlus | COUMARINS | - |
dc.subject.keywordPlus | 2-ARYLPHENOLS | - |
dc.subject.keywordPlus | FRUTICOSA | - |
dc.subject.keywordPlus | ALCOHOLS | - |
dc.subject.keywordPlus | BOND ACTIVATION | - |
dc.subject.keywordPlus | OXIDATIVE CARBONYLATION | - |
dc.subject.keywordPlus | CHROMONES | - |
dc.subject.keywordPlus | FLAVONES | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordPlus | CYCLIZATION | - |
dc.subject.keywordPlus | COUMARINS | - |
dc.subject.keywordPlus | 2-ARYLPHENOLS | - |
dc.subject.keywordPlus | FRUTICOSA | - |
dc.subject.keywordPlus | ALCOHOLS | - |
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