Novel polypyrrolic-based systems for the detection of biologically important molecular species = 생물학적 중요 분자 탐지를 위한 폴리피롤 화합물 기반의 새로운 시스템 연구

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New A2B-type-(Mn+)-corrolate compounds (3 structural studies) that include the oxo(5,15-bis(pentafluorophenyl)-10-(R)corrolatochromium(V) [R = 2- / 3-thienyl (1a / 2a), 3-thianaphthyl (3a)] species are reported. The first examples of meso-A2(thienyl) and Cr-A2B-corrole types are represented herein. Charac-terization includes CV, EPR, 2-D (1H, 13C) NMR and UV-Vis spectroscopy, mass-spectrometry and elemental analysis. Compounds 1a-3a have enabled analyte binding capacity studies. [Cu2+???(O)Cr(cor)] binding repre-sents a new selective mode of corrole-based detection, whereas free-base A2B-corroles exhibited limited Mn+-selectivity. The 10-position substitution affects optical profiles in analyte titrations. A limited amount of PPh3 O-atom uptake from the [(O)Cr(cor)] was also demonstrated. Various R/Ar?functionalized Sn(5,10,15?tris(pentafluorophenyl)corrolate) derivatives are reported herein including the first Fc?Sn?corrolate species. The isopropyl?, sec?butyl?, 2?methyl?n?butyl?, phenyl?, 2?thienyl?, ferrocenyl?tin species have been prepared and characterized through 1H?, 13C?, 119Sn?, and HMQC?NMR spectroscopy, mass spectrometry, UV?vis spectroscopy, photoluminescent spectroscopy, and cyclic voltammetry studies. JC/H?Sn NMR spectroscopic couplings and ring?current effects (upfield shifting) were determined for the R?Sn axial protons and carbons. Such NMR spectroscopic aspects are discussed for these model systems. Compound Sn?Ph bond cleavage was achieved by treatment with I2. A novel rechargeable meso-aryl Bodipy?based Cys sensing ensemble has been developed (“turn on,” ΦF = <0.05 ? 0.72, limit of detection = 6.0 × 10?6 M) with exceptional selectivity over homocysteine, N?acetylcysteine, glutathione (GSH) and methionine. New reversible Bodipy?based zinc (II) ensemble for selective “turn?on” fluorescence sensing of ATP and PPi in aqueous media was developed. The sensing mode involves demetallation of the weakly fluorescent 1?Zn2+ by ATP and PPi, leading to...
Churchill, David G.researcher처칠
한국과학기술원 : 화학과,
Issue Date
566080/325007  / 020085368

학위논문(박사) - 한국과학기술원 : 화학과, 2013.8, [ ix, 197 p. ]


corrole; 화학센싱; 메탈복합체; Bodipy; 메탈코롤; 코롤; metallocorrole; Bodipy; metal complex; chemosensing

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