DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lim, Dae-Sik | - |
dc.contributor.advisor | 임대식 | - |
dc.contributor.advisor | Chung, Jae-Hoon | - |
dc.contributor.advisor | 정재훈 | - |
dc.contributor.author | Song, Ji-Yun | - |
dc.contributor.author | 송지윤 | - |
dc.date.accessioned | 2015-04-23T02:08:35Z | - |
dc.date.available | 2015-04-23T02:08:35Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=567200&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/196207 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2011., [ vii, 120 p. ] | - |
dc.description.abstract | Liver cancer development follows a multistep process that includes epigenetic changes beginning at the initiation stage, changes that have been studied for their potential diagnostic value. Here, we examined long-term, cancer-associated epigenetic changes during carcinogenesis using a mouse model of liver cancer. WW45-haploinsufficient (WW45+/-) mice developed liver cancer after 12 months due to dysregulation of the Hippo pathway and consequent Yap overexpression. There was no pathological sign of neoplastic regions in the livers of 10-month-old WW45+/-mice but whole gene expression patterns statistically proved the resemblance between 10-month-old livers and hepatomas from WW45+/-mice. We found epigenetic features in the livers of 10-month-old WW45+/-mice which were already distinctive from the wild-type counterparts prior to tumorigenesises. H19 ICR showed loss-of-imprinting in two steps and allelic histone marker signature during tumorigenesis showed similarity with ES cells. Progressive cancer pathognomonic global hypomethylation was a characteristic post-10-month feature and was well reflected in retrotransposons. Heterochromatic histone modifications also decreased in retrotransposons after 10 month in the liver of WW45+/-mice. This study showed potential epigenetic features for cancer prognostic use and supported the epigenetic progenitor model of cancer. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Liver cancer | - |
dc.subject | Tumorigenesis | - |
dc.subject | DNA methylation | - |
dc.subject | WW45 | - |
dc.subject | 종양 후생유전학 | - |
dc.subject | 간암 | - |
dc.subject | 종양발생 | - |
dc.subject | DNA 메틸화 | - |
dc.subject | WW45 | - |
dc.subject | Cancer epigenetics | - |
dc.title | Epigenetic changes prior to tumorigenesis in mouse model of liver cancer | - |
dc.title.alternative | 생쥐 모델을 이용한 간암 생성 이전 후생유전학적 변화 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 567200/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020047963 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.localauthor | 임대식 | - |
dc.contributor.localauthor | Chung, Jae-Hoon | - |
dc.contributor.localauthor | 정재훈 | - |
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