DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Ho-Nam | ko |
dc.contributor.author | Jung, Kwonsu | ko |
dc.contributor.author | Choi, Jin-Dal-Rae | ko |
dc.contributor.author | Lee, Joon Chul | ko |
dc.contributor.author | Woo, Hee-Chul | ko |
dc.date.accessioned | 2015-04-06T05:47:00Z | - |
dc.date.available | 2015-04-06T05:47:00Z | - |
dc.date.created | 2014-11-24 | - |
dc.date.created | 2014-11-24 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.citation | BIOTECHNOLOGY ADVANCES, v.32, no.2, pp.514 - 525 | - |
dc.identifier.issn | 0734-9750 | - |
dc.identifier.uri | http://hdl.handle.net/10203/194699 | - |
dc.description.abstract | A multi-stage continuous high cell density culture (MSC-HCDC) system makes it possible to achieve high productivity together with high product titer of many bioproducts. For long-term continuous operation of MSC-HCDC systems, the cell retention time and hydraulic retention time must be decoupled and strains (bacteria, yeast, plant, and animal cells) must be stable. MSC-HCDC systems are suitable for low-value high-volume extracellular products such as fuel ethanol, lactic acid or volatile fatty acids, and high-value products such as monoclonal antibodies as well as intracellular products such as polyhydroxybutyric acid (PHB), microbial lipids or a number of therapeutics. Better understanding of the fermentation kinetics of a specific product and reliable high-density culture methods for the product-generating microorganisms will facilitate timely industrialization of MSC-HCDC systems for products that are currently obtained in fed-batch bioreactors. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | FED-BATCH CULTURE | - |
dc.subject | HOLLOW-FIBER BIOREACTOR | - |
dc.subject | RECOMBINANT ANTIBODY-PRODUCTION | - |
dc.subject | FILTER PERFUSION SYSTEM | - |
dc.subject | ETHANOL-PRODUCTION | - |
dc.subject | ALCALIGENES-EUTROPHUS | - |
dc.subject | MEMBRANE BIOREACTORS | - |
dc.subject | RECYCLE BIOREACTOR | - |
dc.subject | IMMOBILIZED CELLS | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.title | Multi-stage continuous high cell density culture systems: A review | - |
dc.type | Article | - |
dc.identifier.wosid | 000343640400022 | - |
dc.identifier.scopusid | 2-s2.0-84895486224 | - |
dc.type.rims | ART | - |
dc.citation.volume | 32 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 514 | - |
dc.citation.endingpage | 525 | - |
dc.citation.publicationname | BIOTECHNOLOGY ADVANCES | - |
dc.identifier.doi | 10.1016/j.biotechadv.2014.01.004 | - |
dc.contributor.localauthor | Chang, Ho-Nam | - |
dc.contributor.nonIdAuthor | Lee, Joon Chul | - |
dc.contributor.nonIdAuthor | Woo, Hee-Chul | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | Multi-stage continuous bioreactors | - |
dc.subject.keywordAuthor | High cell density culture | - |
dc.subject.keywordAuthor | Product titer improvement | - |
dc.subject.keywordAuthor | Productivity improvement | - |
dc.subject.keywordPlus | FED-BATCH CULTURE | - |
dc.subject.keywordPlus | HOLLOW-FIBER BIOREACTOR | - |
dc.subject.keywordPlus | RECOMBINANT ANTIBODY-PRODUCTION | - |
dc.subject.keywordPlus | FILTER PERFUSION SYSTEM | - |
dc.subject.keywordPlus | ETHANOL-PRODUCTION | - |
dc.subject.keywordPlus | ALCALIGENES-EUTROPHUS | - |
dc.subject.keywordPlus | MEMBRANE BIOREACTORS | - |
dc.subject.keywordPlus | RECYCLE BIOREACTOR | - |
dc.subject.keywordPlus | IMMOBILIZED CELLS | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.