DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Ji-Sun | ko |
dc.contributor.author | Yoon, Jungsoon | ko |
dc.contributor.author | Kim, Yeon-Jung | ko |
dc.contributor.author | Kang, Kyuho | ko |
dc.contributor.author | Woo, Sunje | ko |
dc.contributor.author | Jung, Dea-Im | ko |
dc.contributor.author | Song, Man Ki | ko |
dc.contributor.author | Kim, Eun-Ha | ko |
dc.contributor.author | Kwon, Hyeok-il | ko |
dc.contributor.author | Choi, Young Ki | ko |
dc.contributor.author | Kim, Jihye | ko |
dc.contributor.author | Lee, Jeewon | ko |
dc.contributor.author | Yoon, Yeup | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Youn, Jin-Won | ko |
dc.date.accessioned | 2015-01-27T02:47:32Z | - |
dc.date.available | 2015-01-27T02:47:32Z | - |
dc.date.created | 2014-07-16 | - |
dc.date.created | 2014-07-16 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF IMMUNOLOGY, v.44, no.8, pp.2360 - 2369 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://hdl.handle.net/10203/193165 | - |
dc.description.abstract | Growing concerns about unpredictable influenza pandemics require a broadly protective vaccine against diverse influenza strains. One of the promising approaches was a T cell-based vaccine, but the narrow breadth of T-cell immunity due to the immunodominance hierarchy established by previous influenza infection and efficacy against only mild challenge condition are important hurdles to overcome. To model T-cell immunodominance hierarchy in humans in an experimental setting, influenza-primed C57BL/6 mice were chosen and boosted with a mixture of vaccinia recombinants, individually expressing consensus sequences from avian, swine, and human isolates of influenza internal proteins. As determined by IFN-gamma ELISPOT and polyfunctional cytokine secretion, the vaccinia recombinants of influenza expanded the breadth of T-cell responses to include subdominant and even minor epitopes. Vaccine groups were successfully protected against 100 LD50 challenges with PR/8/34 and highly pathogenic avian influenza H5N1, which contained the identical dominant NP366 epitope. Interestingly, in challenge with pandemic A/Cal/04/2009 containing mutations in the dominant epitope, only the group vaccinated with rVV-NP + PA showed improved protection. Taken together, a vaccinia-based influenza vaccine expressing conserved internal proteins improved the breadth of influenza-specific T-cell immunity and provided heterosubtypic protection against immunologically close as well as distant influenza strains. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | T-CELL IMMUNODOMINANCE | - |
dc.subject | A VIRUS | - |
dc.subject | CHALLENGE | - |
dc.subject | INFECTION | - |
dc.subject | PROTEIN | - |
dc.subject | EPITOPE | - |
dc.subject | IMMUNIZATION | - |
dc.subject | RESPONSES | - |
dc.subject | MEMORY | - |
dc.subject | HUMANS | - |
dc.title | Vaccinia-based influenza vaccine overcomes previously induced immunodominance hierarchy for heterosubtypic protection | - |
dc.type | Article | - |
dc.identifier.wosid | 000340584800017 | - |
dc.identifier.scopusid | 2-s2.0-84906082332 | - |
dc.type.rims | ART | - |
dc.citation.volume | 44 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 2360 | - |
dc.citation.endingpage | 2369 | - |
dc.citation.publicationname | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.identifier.doi | 10.1002/eji.201344005 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Kwon, Ji-Sun | - |
dc.contributor.nonIdAuthor | Yoon, Jungsoon | - |
dc.contributor.nonIdAuthor | Kim, Yeon-Jung | - |
dc.contributor.nonIdAuthor | Kang, Kyuho | - |
dc.contributor.nonIdAuthor | Woo, Sunje | - |
dc.contributor.nonIdAuthor | Jung, Dea-Im | - |
dc.contributor.nonIdAuthor | Song, Man Ki | - |
dc.contributor.nonIdAuthor | Kim, Eun-Ha | - |
dc.contributor.nonIdAuthor | Kwon, Hyeok-il | - |
dc.contributor.nonIdAuthor | Choi, Young Ki | - |
dc.contributor.nonIdAuthor | Lee, Jeewon | - |
dc.contributor.nonIdAuthor | Yoon, Yeup | - |
dc.contributor.nonIdAuthor | Youn, Jin-Won | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Consensus sequence | - |
dc.subject.keywordAuthor | Heterosubtypic protection | - |
dc.subject.keywordAuthor | Immunodominance hierarchy | - |
dc.subject.keywordAuthor | T-cell immunity | - |
dc.subject.keywordAuthor | Universal influenza vaccine | - |
dc.subject.keywordPlus | T-CELL IMMUNODOMINANCE | - |
dc.subject.keywordPlus | A VIRUS | - |
dc.subject.keywordPlus | CHALLENGE | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | EPITOPE | - |
dc.subject.keywordPlus | IMMUNIZATION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | HUMANS | - |
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