DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Sunkyu | ko |
dc.contributor.author | Morrison, Karen C. | ko |
dc.contributor.author | Hergenrother, Paul J. | ko |
dc.contributor.author | Movassaghi, Mohammad | ko |
dc.date.accessioned | 2015-01-27T02:07:14Z | - |
dc.date.available | 2015-01-27T02:07:14Z | - |
dc.date.created | 2014-07-07 | - |
dc.date.created | 2014-07-07 | - |
dc.date.created | 2014-07-07 | - |
dc.date.created | 2014-07-07 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.citation | JOURNAL OF ORGANIC CHEMISTRY, v.79, no.2, pp.473 - 486 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | http://hdl.handle.net/10203/193063 | - |
dc.description.abstract | A full account of our concise and enantioselective total syntheses of all known (-)-trigonoliimine alkaloids is described. Our retrobiosynthetic analysis of these natural products enabled identification of a single bistryptamine precursor as a precursor to all known trigonoliimines through a sequence of transformations involving asymmetric oxidation and reorganization. Our enantioselective syntheses of these alkaloids enabled the revision of the absolute stereochemistry of (-)-trigonoliimines A, B, and C. We report that trigonoliimines A, B, C and structurally related compounds showed weak anticancer activities against HeLa and U-937 cells. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (-)-Trigonoliimines | - |
dc.type | Article | - |
dc.identifier.wosid | 000330099000001 | - |
dc.identifier.scopusid | 2-s2.0-84896802062 | - |
dc.type.rims | ART | - |
dc.citation.volume | 79 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 473 | - |
dc.citation.endingpage | 486 | - |
dc.citation.publicationname | JOURNAL OF ORGANIC CHEMISTRY | - |
dc.identifier.doi | 10.1021/jo4020358 | - |
dc.contributor.localauthor | Han, Sunkyu | - |
dc.contributor.nonIdAuthor | Morrison, Karen C. | - |
dc.contributor.nonIdAuthor | Hergenrother, Paul J. | - |
dc.contributor.nonIdAuthor | Movassaghi, Mohammad | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | STEREOCONTROLLED TOTAL-SYNTHESIS | - |
dc.subject.keywordPlus | CONCISE TOTAL-SYNTHESIS | - |
dc.subject.keywordPlus | ENANTIOSELECTIVE EPOXIDATION | - |
dc.subject.keywordPlus | OXIDATIVE REARRANGEMENT | - |
dc.subject.keywordPlus | ASYMMETRIC EPOXIDATION | - |
dc.subject.keywordPlus | STEREOSELECTIVE-SYNTHESIS | - |
dc.subject.keywordPlus | BENZANNULATION REACTIONS | - |
dc.subject.keywordPlus | (+/-)-TRIGONOLIIMINE C | - |
dc.subject.keywordPlus | TRIFLUOROACETIC-ACID | - |
dc.subject.keywordPlus | BIOMIMETIC SYNTHESIS | - |
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