DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, H | ko |
dc.contributor.author | Lee, E | ko |
dc.contributor.author | Kim, DK | ko |
dc.contributor.author | Jang, NK | ko |
dc.contributor.author | Jeong, YY | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2014-12-09T01:34:37Z | - |
dc.date.available | 2014-12-09T01:34:37Z | - |
dc.date.created | 2014-08-29 | - |
dc.date.created | 2014-08-29 | - |
dc.date.issued | 2006-06 | - |
dc.identifier.citation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.128, no.22, pp.7383 - 7389 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10203/192432 | - |
dc.description.abstract | We report the fabrication and characterization of antifouling polymer-coated magnetic nanoparticles as nanoprobes for magnetic resonance ( MR) contrast agents. Magnetite superparamagnetic iron oxide nanoparticles ( SPION) were coated with the protein- or cell-resistant polymer, poly( TMSMA-r-PEGMA), to generate stable, protein- resistant MR probes. Coated magnetic nanoparticles synthesized using two different preparation methods ( in situ and stepwise, respectively) were both well dispersed in PBS buffer at a variety of pH conditions ( pH 1-10). In addition, dynamic light scattering data revealed that their sizes were not altered even after 24 h of incubation in 10% serum containing cell culture medium, indicative of a lack of protein adsorption on their surfaces. When the antibiofouling polymer-coated SPION were incubated with macrophage cells, uptake was significantly lower in comparison to that of the popular contrast agent, Feridex I. V., suggesting that the polymer-coated SPION can be long-circulated in plasma by escaping from uptake by the reticular endothelial system ( RES) such as macrophages. Indeed, when the coated SPION were administered to tumor xenograft mice by intravenous injection, the tumor could be detected in T2-weighted MR images within 1 h as a result of the accumulation of the nanomagnets within the tumor site. Although the poly( TMSMA-r-PEGMA)-coated SPION do not have any targeting ligands on their surface, they are potentially useful for cancer diagnosis in vivo. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | PHYSICOCHEMICAL CHARACTERISTICS | - |
dc.subject | BIOMEDICAL APPLICATIONS | - |
dc.subject | MACROPHAGE ENDOCYTOSIS | - |
dc.subject | MICROFLUIDIC CHANNELS | - |
dc.subject | SURFACE MODIFICATION | - |
dc.subject | INTRACELLULAR UPTAKE | - |
dc.subject | AQUEOUS DISPERSIONS | - |
dc.subject | MRI DETECTION | - |
dc.subject | CELLS | - |
dc.subject | PARTICLES | - |
dc.title | Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging | - |
dc.type | Article | - |
dc.identifier.wosid | 000237931700059 | - |
dc.type.rims | ART | - |
dc.citation.volume | 128 | - |
dc.citation.issue | 22 | - |
dc.citation.beginningpage | 7383 | - |
dc.citation.endingpage | 7389 | - |
dc.citation.publicationname | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.identifier.doi | 10.1021/ja061529k | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Lee, H | - |
dc.contributor.nonIdAuthor | Lee, E | - |
dc.contributor.nonIdAuthor | Kim, DK | - |
dc.contributor.nonIdAuthor | Jang, NK | - |
dc.contributor.nonIdAuthor | Jeong, YY | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PHYSICOCHEMICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | BIOMEDICAL APPLICATIONS | - |
dc.subject.keywordPlus | MACROPHAGE ENDOCYTOSIS | - |
dc.subject.keywordPlus | MICROFLUIDIC CHANNELS | - |
dc.subject.keywordPlus | SURFACE MODIFICATION | - |
dc.subject.keywordPlus | INTRACELLULAR UPTAKE | - |
dc.subject.keywordPlus | AQUEOUS DISPERSIONS | - |
dc.subject.keywordPlus | MRI DETECTION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PARTICLES | - |
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