DC Field | Value | Language |
---|---|---|
dc.contributor.author | Schenten, Dominik | ko |
dc.contributor.author | Nish, Simone A. | ko |
dc.contributor.author | Yu, Shuang | ko |
dc.contributor.author | Yan, Xiting | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.contributor.author | Brodsky, Igor | ko |
dc.contributor.author | Pasman, Lesley | ko |
dc.contributor.author | Yordy, Brian | ko |
dc.contributor.author | Wunderlich, F. Thomas | ko |
dc.contributor.author | Bruening, Jens C. | ko |
dc.contributor.author | Zhao, Hongyu | ko |
dc.contributor.author | Medzhitov, Ruslan | ko |
dc.date.accessioned | 2014-11-25T06:16:10Z | - |
dc.date.available | 2014-11-25T06:16:10Z | - |
dc.date.created | 2014-04-01 | - |
dc.date.created | 2014-04-01 | - |
dc.date.created | 2014-04-01 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.citation | IMMUNITY, v.40, no.5, pp.814 - 814 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/191157 | - |
dc.description.abstract | Innate immune recognition controls adaptive immune responses through multiple mechanisms. The MyD88 signaling adaptor operates in many cell types downstream of Toll-like receptors (TLRs) and interleukin-1 (IL-1) receptor family members. Cell-type-specific functions of MyD88 signaling remain poorly characterized. Here, we have shown that the T cell-specific ablation of MyD88 in mice impairs not only T helper 17 (Th17) cell responses, but also Th1 cell responses. MyD88 relayed signals of TLR-induced IL-1, which became dispensable for Th1 cell responses in the absence of T regulatory (Treg) cells. Treg cell-specific ablation of MyD88 had no effect, suggesting that IL-1 acts on naive CD4(+) T cells instead of Treg cells themselves. Together, these findings demonstrate that IL-1 renders naive CD4(+) T cells refractory to Treg cell-mediated suppression in order to allow their differentiation into Th1 cells. In addition, IL-1 was also important for the generation of functional CD4(+) memory T cells. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | INNATE IMMUNE-SYSTEM | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | MEDIATED SUPPRESSION | - |
dc.subject | RESPONSE LATE | - |
dc.subject | CUTTING EDGE | - |
dc.subject | BURN INJURY | - |
dc.subject | IL-1 | - |
dc.subject | EXPRESSION | - |
dc.subject | EXPANSION | - |
dc.subject | DIFFERENTIATION | - |
dc.title | Signaling through the Adaptor Molecule MyD88 in CD4(+) T Cells Is Required to Overcome Suppression by Regulatory T Cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000336026100018 | - |
dc.identifier.scopusid | 2-s2.0-84892474632 | - |
dc.type.rims | ART | - |
dc.citation.volume | 40 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 814 | - |
dc.citation.endingpage | 814 | - |
dc.citation.publicationname | IMMUNITY | - |
dc.identifier.doi | 10.1016/j.immuni.2013.10.023 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.contributor.nonIdAuthor | Schenten, Dominik | - |
dc.contributor.nonIdAuthor | Nish, Simone A. | - |
dc.contributor.nonIdAuthor | Yu, Shuang | - |
dc.contributor.nonIdAuthor | Yan, Xiting | - |
dc.contributor.nonIdAuthor | Brodsky, Igor | - |
dc.contributor.nonIdAuthor | Pasman, Lesley | - |
dc.contributor.nonIdAuthor | Yordy, Brian | - |
dc.contributor.nonIdAuthor | Wunderlich, F. Thomas | - |
dc.contributor.nonIdAuthor | Bruening, Jens C. | - |
dc.contributor.nonIdAuthor | Zhao, Hongyu | - |
dc.contributor.nonIdAuthor | Medzhitov, Ruslan | - |
dc.type.journalArticle | Correction | - |
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