DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Aee-Young | ko |
dc.contributor.author | Chae, Yeon-Su | ko |
dc.contributor.author | Lee, Seung-Hee | ko |
dc.contributor.author | Kaang, Bong-Kiun | ko |
dc.contributor.author | Lee, Seonghoon | ko |
dc.date.accessioned | 2014-09-04T08:30:59Z | - |
dc.date.available | 2014-09-04T08:30:59Z | - |
dc.date.created | 2014-08-04 | - |
dc.date.created | 2014-08-04 | - |
dc.date.created | 2014-08-04 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.citation | JOURNAL OF PHYSICAL CHEMISTRY B, v.117, no.17, pp.4779 - 4788 | - |
dc.identifier.issn | 1520-6106 | - |
dc.identifier.uri | http://hdl.handle.net/10203/190027 | - |
dc.description.abstract | The structural and functional plasticity of Aplysia mechanosensory presynaptic neurons has been studied in relation with the mechanism underlying learning and memory. Long-term facilitation. (LTF), which is a well-known cellular model for long-term memory in Aplysia, is accompanied by new synaptic structural growth or change. We developed a combined atomic force microscope and confocal laser scanning microscope (AFM-CLSM) system integrated with a MATLAB routine for image processing to concurrently obtain high-resolution 3-dimensional (3D) outer surface morphological images and 3D interior fluorescence images. With our combined AFM-CLSM system, volumetric changes in the presynaptic structures (varicosities) of Aplysia live sensory-motor neuron cocultures were observed. The spatial distribution of synaptic vesicle molecules in the preexisting varicosities was monitored together with a volumetric change in the varicosities. Our combined AFM-CLSM system is successfully adapted for measuring learning related structural changes and the movement of synaptic molecules in the single live neuron through interaction force and fluorescence imaging. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | TERM SYNAPTIC FACILITATION | - |
dc.subject | SENSORY NEURONS | - |
dc.subject | DENDRITIC SPINES | - |
dc.subject | PROBE MICROSCOPE | - |
dc.subject | RNA INTERFERENCE | - |
dc.subject | TRKB RECEPTORS | - |
dc.subject | MOTOR SYNAPSES | - |
dc.subject | MEMORY STORAGE | - |
dc.subject | GROWTH | - |
dc.subject | CELLS | - |
dc.title | Presynaptic Structure of Aplysia Single Live Neuron by Atomic Force and Confocal Laser Scanning Microscope | - |
dc.type | Article | - |
dc.identifier.wosid | 000318536700006 | - |
dc.identifier.scopusid | 2-s2.0-84877011970 | - |
dc.type.rims | ART | - |
dc.citation.volume | 117 | - |
dc.citation.issue | 17 | - |
dc.citation.beginningpage | 4779 | - |
dc.citation.endingpage | 4788 | - |
dc.citation.publicationname | JOURNAL OF PHYSICAL CHEMISTRY B | - |
dc.identifier.doi | 10.1021/jp3115308 | - |
dc.contributor.localauthor | Lee, Seung-Hee | - |
dc.contributor.nonIdAuthor | Park, Aee-Young | - |
dc.contributor.nonIdAuthor | Chae, Yeon-Su | - |
dc.contributor.nonIdAuthor | Kaang, Bong-Kiun | - |
dc.contributor.nonIdAuthor | Lee, Seonghoon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TERM SYNAPTIC FACILITATION | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | DENDRITIC SPINES | - |
dc.subject.keywordPlus | PROBE MICROSCOPE | - |
dc.subject.keywordPlus | RNA INTERFERENCE | - |
dc.subject.keywordPlus | TRKB RECEPTORS | - |
dc.subject.keywordPlus | MOTOR SYNAPSES | - |
dc.subject.keywordPlus | MEMORY STORAGE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CELLS | - |
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