DC Field | Value | Language |
---|---|---|
dc.contributor.author | Won, Hyejung | ko |
dc.contributor.author | Mah, Won | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2014-09-04T08:30:58Z | - |
dc.date.available | 2014-09-04T08:30:58Z | - |
dc.date.created | 2014-07-15 | - |
dc.date.created | 2014-07-15 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.identifier.issn | 1662-5099 | - |
dc.identifier.uri | http://hdl.handle.net/10203/190026 | - |
dc.description.abstract | Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by impairments in social interaction and communication and restricted and repetitive interests/behaviors. Advances in human genomics have identified a large number of genetic variations associated with ASD. These associations are being rapidly verified by a growing number of studies using a variety of approaches, including mouse genetics. These studies have also identified key mechanisms underlying the pathogenesis of ASD, many of which involve synaptic dysfunctions, and have investigated novel, mechanism-based therapeutic strategies. This review will try to integrate these three key aspects of ASD research: human genetics, animal models, and potential treatments. Continued efforts in this direction should ultimately reveal core mechanisms that account for a larger fraction of ASD cases and identify neural mechanisms associated with specific ASD symptoms, providing important clues to efficient ASD treatment. | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.title | Autism spectrum disorder causes, mechanisms, and treatments: Focus on neuronal synapses | - |
dc.type | Article | - |
dc.identifier.scopusid | 2-s2.0-84880642453 | - |
dc.type.rims | ART | - |
dc.citation.publicationname | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.identifier.doi | 10.3389/fnmol.2013.00019 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.subject.keywordAuthor | Animal model | - |
dc.subject.keywordAuthor | Autism spectrum disorder | - |
dc.subject.keywordAuthor | Genetics | - |
dc.subject.keywordAuthor | Synapse | - |
dc.subject.keywordAuthor | Synaptopathy | - |
dc.subject.keywordAuthor | Therapeutics | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.