Cross-linked Iron Oxide Nanoparticles for Therapeutic Engineering and in Vivo Monitoring of Mesenchymal Stem Cells in Cerebral Ischemia Model

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Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2014-03
Language
English
Article Type
Article
Keywords

GENE TRANSFECTION; STROKE; TRANSPLANTATION; DELIVERY; ANGIOGENESIS; ADULT

Citation

MACROMOLECULAR BIOSCIENCE, v.14, no.3, pp.380 - 389

ISSN
1616-5187
DOI
10.1002/mabi.201300340
URI
http://hdl.handle.net/10203/189225
Appears in Collection
BS-Journal Papers(저널논문)
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