DC Field | Value | Language |
---|---|---|
dc.contributor.author | Anh Thu Ngoc Lam | ko |
dc.contributor.author | Yoon, Jinha | ko |
dc.contributor.author | Ganbold, Erdene-Ochir | ko |
dc.contributor.author | Singh, Dheeraj K. | ko |
dc.contributor.author | Kim, Doseok | ko |
dc.contributor.author | Cho, Kwang-Hwi | ko |
dc.contributor.author | Son, Sang Jun | ko |
dc.contributor.author | Choo, Jaebum | ko |
dc.contributor.author | Lee, So Yeong | ko |
dc.contributor.author | Kim, Sehun | ko |
dc.contributor.author | Joo, Sang-Woo | ko |
dc.date.accessioned | 2014-08-29T02:49:47Z | - |
dc.date.available | 2014-08-29T02:49:47Z | - |
dc.date.created | 2014-06-10 | - |
dc.date.created | 2014-06-10 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.citation | JOURNAL OF COLLOID AND INTERFACE SCIENCE, v.425, pp.96 - 101 | - |
dc.identifier.issn | 0021-9797 | - |
dc.identifier.uri | http://hdl.handle.net/10203/189013 | - |
dc.description.abstract | We investigated interfacial behaviors of erlotinib (EL) on gold nanoparticles (AuNPs) by means of Raman spectroscopy. The adsorption reactions and structures of EL on AuNP surfaces were examined by UV-Vis absorption spectroscopy and surface-enhanced Raman scattering (SERS). Density functional theory calculations were performed to estimate the energetic stabilities of the drug-AuNP composites. Among the binding units in EL, the acetylenic C equivalent to C group was calculated to be the most strongly binding on the AuNP cluster atoms, consistent with the SERS spectra. The concentration-dependent SERS spectra indicated that similar to 10(-5) M of EL exhibited the highest SERS signals. The attached EL appeared to desorb more efficiently with 2 mM glutathione than with cell culture media. The lack of a strong SERS signal of EL in the darkfield microscopy images of AuNP-EL complexes suggested almost complete desorption of EL inside cells. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | SURFACE-ENHANCED RAMAN | - |
dc.subject | CANCER-CELLS | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | SCATTERING | - |
dc.subject | SILVER | - |
dc.subject | RELEASE | - |
dc.subject | BEHAVIOR | - |
dc.subject | DRUGS | - |
dc.title | Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles | - |
dc.type | Article | - |
dc.identifier.wosid | 000335620500014 | - |
dc.identifier.scopusid | 2-s2.0-84898635968 | - |
dc.type.rims | ART | - |
dc.citation.volume | 425 | - |
dc.citation.beginningpage | 96 | - |
dc.citation.endingpage | 101 | - |
dc.citation.publicationname | JOURNAL OF COLLOID AND INTERFACE SCIENCE | - |
dc.identifier.doi | 10.1016/j.jcis.2014.03.032 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Sehun | - |
dc.contributor.nonIdAuthor | Anh Thu Ngoc Lam | - |
dc.contributor.nonIdAuthor | Yoon, Jinha | - |
dc.contributor.nonIdAuthor | Ganbold, Erdene-Ochir | - |
dc.contributor.nonIdAuthor | Singh, Dheeraj K. | - |
dc.contributor.nonIdAuthor | Kim, Doseok | - |
dc.contributor.nonIdAuthor | Cho, Kwang-Hwi | - |
dc.contributor.nonIdAuthor | Son, Sang Jun | - |
dc.contributor.nonIdAuthor | Choo, Jaebum | - |
dc.contributor.nonIdAuthor | Lee, So Yeong | - |
dc.contributor.nonIdAuthor | Joo, Sang-Woo | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Raman spectroscopy | - |
dc.subject.keywordAuthor | Erlotinib | - |
dc.subject.keywordAuthor | Gold nanoparticles | - |
dc.subject.keywordAuthor | Interfacial structures | - |
dc.subject.keywordAuthor | Density functional theory | - |
dc.subject.keywordPlus | SURFACE-ENHANCED RAMAN | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | SCATTERING | - |
dc.subject.keywordPlus | SILVER | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | DRUGS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.