Somatic deletions implicated in functional diversity of brain cells of individuals with schizophrenia and unaffected controls

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dc.contributor.authorKim, Jun-Hoko
dc.contributor.authorShin, Jong-Yeonko
dc.contributor.authorKim, Jong-Ilko
dc.contributor.authorSeo, Jeong-Sunko
dc.contributor.authorWebster, Maree J.ko
dc.contributor.authorLee, Doheonko
dc.contributor.authorKim, Sanghyeonko
dc.date.accessioned2014-08-29T01:05:30Z-
dc.date.available2014-08-29T01:05:30Z-
dc.date.created2014-02-17-
dc.date.created2014-02-17-
dc.date.issued2014-01-
dc.identifier.citationSCIENTIFIC REPORTS, v.4-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10203/188685-
dc.description.abstractWhile somatic DNA copy number variations (CNVs) have been identified in multiple tissues from normal people, they have not been well studied in brain tissues from individuals with psychiatric disorders. With ultrahigh depth sequencing data, we developed an integrated pipeline for calling somatic deletions using data from multiple tissues of the same individual or a single tissue type taken from multiple individuals. Using the pipelines, we identified 106 somatic deletions in DNA from prefrontal cortex (PFC) and/or cerebellum of two normal controls subjects and/or three individuals with schizophrenia. We then validated somatic deletions in 18 genic and in 1 intergenic region. Somatic deletions in BOD1 and CBX3 were reconfirmed using DNA isolated from non-pyramidal neurons and from cells in white matter using laser capture microdissection (LCM). Our results suggest that somatic deletions may affect metabolic processes and brain development in a region specific manner.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectCOPY-NUMBER-VARIATION-
dc.subjectNEUROPATHOLOGY CONSORTIUM-
dc.subjectMOLECULAR ABNORMALITIES-
dc.subjectPREFRONTAL CORTEX-
dc.subjectHUMAN TISSUES-
dc.subjectGENOME-
dc.subjectNEURONS-
dc.subjectSCALE-
dc.subjectRETROTRANSPOSITION-
dc.subjectCLASSIFICATION-
dc.titleSomatic deletions implicated in functional diversity of brain cells of individuals with schizophrenia and unaffected controls-
dc.typeArticle-
dc.identifier.wosid000330044400005-
dc.identifier.scopusid2-s2.0-84892970354-
dc.type.rimsART-
dc.citation.volume4-
dc.citation.publicationnameSCIENTIFIC REPORTS-
dc.identifier.doi10.1038/srep03807-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, Doheon-
dc.contributor.nonIdAuthorShin, Jong-Yeon-
dc.contributor.nonIdAuthorKim, Jong-Il-
dc.contributor.nonIdAuthorSeo, Jeong-Sun-
dc.contributor.nonIdAuthorWebster, Maree J.-
dc.contributor.nonIdAuthorKim, Sanghyeon-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCOPY-NUMBER-VARIATION-
dc.subject.keywordPlusNEUROPATHOLOGY CONSORTIUM-
dc.subject.keywordPlusMOLECULAR ABNORMALITIES-
dc.subject.keywordPlusPREFRONTAL CORTEX-
dc.subject.keywordPlusHUMAN TISSUES-
dc.subject.keywordPlusGENOME-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusSCALE-
dc.subject.keywordPlusRETROTRANSPOSITION-
dc.subject.keywordPlusCLASSIFICATION-
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