DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lo, Justin H. | ko |
dc.contributor.author | von Maltzahn, Geoffrey | ko |
dc.contributor.author | Douglass, Jacqueline | ko |
dc.contributor.author | Park, Ji-Ho | ko |
dc.contributor.author | Sailor, Michael J. | ko |
dc.contributor.author | Ruoslahti, Erkki | ko |
dc.contributor.author | Bhatia, Sangeeta N. | ko |
dc.date.accessioned | 2014-08-28T08:16:50Z | - |
dc.date.available | 2014-08-28T08:16:50Z | - |
dc.date.created | 2013-10-22 | - |
dc.date.created | 2013-10-22 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.citation | JOURNAL OF MATERIALS CHEMISTRY B, v.1, no.39, pp.5235 - 5240 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.uri | http://hdl.handle.net/10203/188455 | - |
dc.description.abstract | The success of nanoparticle-based cancer therapies ultimately depends on their ability to selectively and efficiently accumulate in regions of disease. Outfitting nanoparticles to actively target tumor-specific markers has improved specificity, yet it remains a challenge to amass adequate therapy in a selective manner. To help address this challenge, we have developed a mechanism of nanoparticle amplification based on stigmergic (environment-modifying) signalling, in which a "Signalling" population of gold nanorods induces localized unveiling of cryptic collagen epitopes, which are in turn targeted by "Responding" nanoparticles bearing gelatin-binding fibronectin fragments. We demonstrate that this two-particle system results in significantly increased, selective recruitment of responding particles. Such amplification strategies have the potential to overcome limitations associated with single-particle targeting by leveraging the capacity of nanoparticles to interact with their environment to create abundant new binding motifs. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | PANCREATIC DUCTAL ADENOCARCINOMA | - |
dc.subject | IN-VIVO | - |
dc.subject | TUMOR | - |
dc.subject | FIBRONECTIN | - |
dc.subject | HYPERTHERMIA | - |
dc.subject | TEMPERATURE | - |
dc.subject | CLEARANCE | - |
dc.subject | NANOWORMS | - |
dc.subject | EFFICACY | - |
dc.title | Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites | - |
dc.type | Article | - |
dc.identifier.wosid | 000324682100008 | - |
dc.identifier.scopusid | 2-s2.0-84884378217 | - |
dc.type.rims | ART | - |
dc.citation.volume | 1 | - |
dc.citation.issue | 39 | - |
dc.citation.beginningpage | 5235 | - |
dc.citation.endingpage | 5240 | - |
dc.citation.publicationname | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.identifier.doi | 10.1039/c3tb20619j | - |
dc.contributor.localauthor | Park, Ji-Ho | - |
dc.contributor.nonIdAuthor | Lo, Justin H. | - |
dc.contributor.nonIdAuthor | von Maltzahn, Geoffrey | - |
dc.contributor.nonIdAuthor | Douglass, Jacqueline | - |
dc.contributor.nonIdAuthor | Sailor, Michael J. | - |
dc.contributor.nonIdAuthor | Ruoslahti, Erkki | - |
dc.contributor.nonIdAuthor | Bhatia, Sangeeta N. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PANCREATIC DUCTAL ADENOCARCINOMA | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | FIBRONECTIN | - |
dc.subject.keywordPlus | HYPERTHERMIA | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | NANOWORMS | - |
dc.subject.keywordPlus | EFFICACY | - |
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