DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신기혁 | ko |
dc.contributor.author | 홍석찬 | ko |
dc.contributor.author | 최은혜 | ko |
dc.contributor.author | 임미경 | ko |
dc.contributor.author | 심승철 | ko |
dc.contributor.author | 주지현 | ko |
dc.contributor.author | 이승효 | ko |
dc.date.accessioned | 2014-08-27T02:32:40Z | - |
dc.date.available | 2014-08-27T02:32:40Z | - |
dc.date.created | 2013-08-13 | - |
dc.date.created | 2013-08-13 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.citation | IMMUNE NETWORK, v.13, no.4, pp.116 - 122 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | http://hdl.handle.net/10203/187384 | - |
dc.description.abstract | This study was conducted to determine whether CD4 T cell responses to citrullinated fibrinogen occur in patients with rheumatoid arthritis (RA), especially in HLA-DR4-positive subjects. Whole peripheral blood mononuclear cells (PBMCs) of RA patients and control subjects were stimulated with citrullinated fibrinogen peptides, and T-cell production of proliferation and proinflammatory cytokines, such as interferon-γ(IFN-γ) and interleukin-17A (IL-17A), were measured. In addition, CD4 T cells from RA patients were stimulated with the citrullinated fibrinogen peptide, Fib-α R84Cit, identified as a DRB1*0401-restricted T cell epitope in HLA-DR4 transgenic mice, and the degree of T cell activation was examined similarly. No proliferative responses to the citrullinated fibrinogen peptides were observed in whole PBMCs or CD4 T cells from RA patients. Furthermore, no increased production of IFN-γor IL-17A was found in whole PBMCs or CD4 T cells stimulated with the citrullinated fibrinogen peptides, although these cells responded to recall antigen, a mixture of tetanus toxoid, purified protein derivative (PPD) from Mycobacterium tuberculosis, and Candida albicans. The results of this study indicate that anti-citrulline immunity in RA patients may be mediated by fibrinogen because there is no evidence of CD4 T cell-mediated immune responses to citrullinated fibrinogen peptides. | - |
dc.language | English | - |
dc.publisher | 대한면역학회 | - |
dc.title | Role of Citrullinated Fibrinogen Peptides in the Activation of CD4 T Cells from Patients with Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 116 | - |
dc.citation.endingpage | 122 | - |
dc.citation.publicationname | IMMUNE NETWORK | - |
dc.identifier.doi | 10.4110/in.2013.13.4.116 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.identifier.kciid | ART001989323 | - |
dc.contributor.localauthor | 이승효 | - |
dc.contributor.nonIdAuthor | 신기혁 | - |
dc.contributor.nonIdAuthor | 홍석찬 | - |
dc.contributor.nonIdAuthor | 최은혜 | - |
dc.contributor.nonIdAuthor | 임미경 | - |
dc.contributor.nonIdAuthor | 심승철 | - |
dc.contributor.nonIdAuthor | 주지현 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Rheumatoid arthritis (RA) | - |
dc.subject.keywordAuthor | Citrullinated fibrinogen (cFBG) | - |
dc.subject.keywordAuthor | CD4 T cell | - |
dc.subject.keywordAuthor | HLA-DR4 | - |
dc.subject.keywordAuthor | Interferon-γ(IFN-γ) | - |
dc.subject.keywordAuthor | Interleukin-17A (IL-17A) | - |
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