DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Honsoul | ko |
dc.contributor.author | Kataru, Raghu P. | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.date.accessioned | 2014-08-27 | - |
dc.date.available | 2014-08-27 | - |
dc.date.created | 2014-03-11 | - |
dc.date.created | 2014-03-11 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.citation | JOURNAL OF CLINICAL INVESTIGATION, v.124, no.3, pp.936 - 942 | - |
dc.identifier.issn | 0021-9738 | - |
dc.identifier.uri | http://hdl.handle.net/10203/187233 | - |
dc.description.abstract | Lymphangiogenesis and lymphatic vessel remodeling are complex biological processes frequently observed during inflammation. Accumulating evidence indicates that inflammation-associated lymphangiogenesis (IAL) is not merely an endpoint event, but actually a phenomenon actively involved in the pathophysiology of various inflammatory disorders. The VEGF-C/VEGFR-3 and VEGF-A/VEGF-R2 signaling pathways are two of the best-studied pathways in JAL. Methods targeting these molecules, such as prolymphangiogenic or antilymphatic treatments, were found to be beneficial in various preclinical and/or clinical studies. This Review focuses on the most recent achievements in the fields of lymphatic biology relevant to inflammatory conditions. Additionally, preclinical and clinical therapies that modulate IAL are summarized. | - |
dc.language | English | - |
dc.publisher | AMER SOC CLINICAL INVESTIGATION INC | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | IDIOPATHIC PULMONARY-FIBROSIS | - |
dc.subject | LYMPH-NODE LYMPHANGIOGENESIS | - |
dc.subject | DENDRITIC CELL-MIGRATION | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | CROHNS-DISEASE | - |
dc.subject | BOWEL-DISEASE | - |
dc.subject | VESSEL ENLARGEMENT | - |
dc.subject | CUTTING EDGE | - |
dc.subject | WOUND REPAIR | - |
dc.title | Inflammation-associated lymphangiogenesis: a double-edged sword? | - |
dc.type | Article | - |
dc.identifier.wosid | 000332347700009 | - |
dc.identifier.scopusid | 2-s2.0-84896790526 | - |
dc.type.rims | ART | - |
dc.citation.volume | 124 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 936 | - |
dc.citation.endingpage | 942 | - |
dc.citation.publicationname | JOURNAL OF CLINICAL INVESTIGATION | - |
dc.identifier.doi | 10.1172/JCI71607 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Kim, Honsoul | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | IDIOPATHIC PULMONARY-FIBROSIS | - |
dc.subject.keywordPlus | LYMPH-NODE LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | DENDRITIC CELL-MIGRATION | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CROHNS-DISEASE | - |
dc.subject.keywordPlus | BOWEL-DISEASE | - |
dc.subject.keywordPlus | VESSEL ENLARGEMENT | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | WOUND REPAIR | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.