DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Ji Hyun | ko |
dc.contributor.author | Lee, Yuhan | ko |
dc.contributor.author | Do, Min Jae | ko |
dc.contributor.author | Jo, Sungduk | ko |
dc.contributor.author | Kim, Jee Seon | ko |
dc.contributor.author | Kim, Byung-Soo | ko |
dc.contributor.author | Im, Gun-Il | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.contributor.author | Lee, Haeshin | ko |
dc.date.accessioned | 2014-08-26T08:30:08Z | - |
dc.date.available | 2014-08-26T08:30:08Z | - |
dc.date.created | 2014-02-14 | - |
dc.date.created | 2014-02-14 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.citation | ACTA BIOMATERIALIA, v.10, no.1, pp.224 - 233 | - |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.uri | http://hdl.handle.net/10203/187137 | - |
dc.description.abstract | Phenol derivative-containing adhesive hydrogels has been widely recognized as having potential for biomedical applications, but their conventional production methods, utilizing a moderate/strong base, alkaline buffers, the addition of oxidizing agents or the use of enzymes, require alternative approaches to improve their biocompatibility. In this study, we report a polymeric, enzyme-mimetic biocatalyst, hematin-grafted chitosan (chitosan-g-hem), which results in effective gelation without the use of alkaline buffers or enzymes. Furthermore, gelation occurs under mild physiological conditions. Chitosan-g-hem biocatalyst (0.01%, w/v) has excellent catalytic properties, forming chitosan-catechol hydrogels rapidly (within 5 min). In vivo adhesive force measurement demonstrated that the hydrogel formed by the chitosan-g-hem activity showed an increase in adhesion force (33.6 +/- 5.9 kPa) compared with the same hydrogel formed by pH-induced catechol oxidation (20.6 +/- 5.5 kPa) in mouse subcutaneous tissue. Using the chitosan-g-hem biocatalyst, other catechol-functionalized polymers (hyaluronic acid-catechol and poly(vinyl alcohol)-catechol) also formed hydrogels, indicating that chitosan-g-hem can be used as a general polymeric catalyst for preparing catechol-containing hydrogels. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | MICHAEL-TYPE ADDITION | - |
dc.subject | HORSERADISH-PEROXIDASE | - |
dc.subject | BIOMEDICAL APPLICATIONS | - |
dc.subject | POLY(ETHYLENE GLYCOL) | - |
dc.subject | TISSUE ADHESIVES | - |
dc.subject | MUSSEL ADHESION | - |
dc.subject | CROSS-LINKING | - |
dc.subject | CHEMISTRY | - |
dc.subject | PROTEINS | - |
dc.subject | DELIVERY | - |
dc.title | Chitosan-g-hematin: Enzyme-mimicking polymeric catalyst for adhesive hydrogels | - |
dc.type | Article | - |
dc.identifier.wosid | 000329893300024 | - |
dc.identifier.scopusid | 2-s2.0-84888637796 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 224 | - |
dc.citation.endingpage | 233 | - |
dc.citation.publicationname | ACTA BIOMATERIALIA | - |
dc.identifier.doi | 10.1016/j.actbio.2013.09.014 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.localauthor | Lee, Haeshin | - |
dc.contributor.nonIdAuthor | Kim, Byung-Soo | - |
dc.contributor.nonIdAuthor | Im, Gun-Il | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Hematin | - |
dc.subject.keywordAuthor | Horseradish peroxidase | - |
dc.subject.keywordAuthor | Catechol | - |
dc.subject.keywordAuthor | Hydrogel | - |
dc.subject.keywordPlus | MICHAEL-TYPE ADDITION | - |
dc.subject.keywordPlus | HORSERADISH-PEROXIDASE | - |
dc.subject.keywordPlus | BIOMEDICAL APPLICATIONS | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | TISSUE ADHESIVES | - |
dc.subject.keywordPlus | MUSSEL ADHESION | - |
dc.subject.keywordPlus | CROSS-LINKING | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | DELIVERY | - |
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